血浆心肌肌钙蛋白Ⅰ和脑钠肽联合检测对小儿肺炎合并心力衰竭的诊断价值

目的 探讨血浆心肌肌钙蛋白Ⅰ （cTnI）和脑钠肽（BNP）联合检测对小儿肺炎合并心力衰竭的诊断价值.方法 选择肺炎合并心力衰竭患儿（心衰组）、同期肺炎急性期患儿（肺炎组）和健康体检儿童（对照组）各30例.心衰组分别在急性期（心衰发作后6～24 h）和恢复期（心衰控制后5～7d）检测cTnI和BNP,并与肺炎组和对照组对照分析.结果 心衰组急性期cTnI和BNP水平显著高于肺炎组和对照组（F=5.303、4.632,均P＜0.05）,肺炎组与对照组cTn1和BNP水平差异无统计学意义（P＞0.05）.心衰组恢复期cTnI和BNP较急性期明显降低（t=4.291、5.393,均P＜0.05）,但与肺炎组合与对照组比较差异无统计学意义（P＞0.05）.结论 联合检测血浆cTnI和BNP是判断小儿肺炎是否合并心衰较为可靠的诊断指标.

Diagnostic value of plasma cTnI and BNP for heart failure complicated with pneumonia in children

Objective To investigate the diagnostic value of plasma cardiac troponin Ⅰ （cTnI） and brain natriuretic peptide （BNP） for heart failure complicated with pneumonia in children.Methods 30 children of heart failure complicated with pneumonia （heart failure group）,30 children with pneumonia in acute phase （pneumonia group） and 30 healthy children （control group） were selected.The levels of plasma cTnI and BNP in the heart failure group were detected in acute phase（6-24h） and recovery phase（5-7d）,and the results were compared with pneumonia group and control group.Results The levels of plasma cTnI and BNP in the heart failure group were significantly higher than those in the pneumonia group and control group（F =5.303,4.632,all P 〈 0.05）.The levels of plasma cTnI and BNP were not significantly different between the pneumonia group and control group（P 〉 0.05）.The levels of plasma cTnI and BNP in recovery phase of the heart failure group were significantly lower than those in acute phase of the heart failure group （t =4.291,5.393,all P 〈 0.05）,but there were no siganificant differences compared with the pneumonia group and control group（P 〉 0.05）.Conclusion The plasma cTnI and BNP maybe a reliable index in the diagnosis of heart failure complicated with pneumonia in children.