泥鳅多糖对实验性糖尿病小鼠血糖血脂的影响

目的　为了解泥鳅多糖 (MAP)对链佐星或四氧嘧啶致糖尿病小鼠血糖、血脂水平的影响。方法采用分别ip链佐星和四氧嘧啶 ,建立两种糖尿病小鼠模型 ,再分别igMAP 2 0 ,6 0mg·kg- 1及阳性对照药苯乙双胍 35mg·kg- 1ig治疗 ,正常对照组则ig等体积生理盐水。连续给药 14d后 ,分别测定各组小鼠血糖、血脂。结果　MAP 2 0 ,6 0mg·kg- 1能明显降低链佐星或四氧嘧啶所致糖尿病小鼠的血糖升高 ;同时 ,MAP还能明显降低链佐星或四氧嘧啶所致糖尿病小鼠血清中的总胆固醇、甘油三酯和低密度脂蛋白胆固醇升高。结论　MAP具有降血糖和调节血脂的作用。

Effects of Misgurnus anguillicaudatus polysaccharides on glycemia and lipidemia in experimental diabetic mice

AIM To investigate the effects of Misgurnus anguillicaudatus polysaccharides (MAP) on hyperglycemia and hyperlipidemia in diabetic mice induced by streptozocin or alloxan. METHODS 〗The living diabetic mice were divided into four groups. Among them, two groups were treated with MAP 20, 60 mg·kg^-1, respectively by ig administration, and one group was given phenformin 35 mg·kg^-1 by ig administration as the positive control, and another group was given normal saline as the diabetic model control. After 14 d of treatment, the blood glucose and the serum lipids content of each group were detected. RESULTS 〗Compared with the diabetic model control group, MAP 20 and 60 mg·kg^-1 could significantly decrease the blood glucose in diabetic mice（P<0.01）. At the same time, the results also shown that MAP could remarkably decrease the level of serum total cholesterol, triglyceride, low-density-lipoprotein cholesterol in diabetic mice. CONCLUSION MAP has modulation effects on the blood glucose and the blood lipids.