| 7－氯苄基四氢巴马汀对豚鼠乳头肌迟后去极，触发活动及猫心单相动作电位的影响 |
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| 引用本文： | 夏国瑾,曾维忠,姚伟星,戴水平,江明性,黄文龙,黄忱亚,彭司勋.7－氯苄基四氢巴马汀对豚鼠乳头肌迟后去极，触发活动及猫心单相动作电位的影响[J].中国药理学与毒理学杂志,1995(3). |
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| 作者姓名： | 夏国瑾 曾维忠 姚伟星 戴水平 江明性 黄文龙 黄忱亚 彭司勋 |
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| 作者单位： | 同济医科大学药理学教研室，中国药科大学药物化学研究室 |
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| 摘 要： | ７一氯苄基四氢巴马汀对豚鼠乳头肌迟后去极，触发活动及猫心单相动作电位的影响夏国瑾，曾维忠，姚伟星，戴水平，江明性，黄文龙，黄忱亚，彭司勋（同济医科大学药理学教研室，武汉４３００３０；中国药科大学药物化学研究室，南京２１０００９）７－氯苄基四氢巴马汀（...
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Effects of 7-chlor-benzyltetrahydropalmatine on delayed after depolarization,triggered activity
in guinea pig papillary muscle and monophasic action potential in cat heart |
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| XIA Guo-Jin,
ZENG Wei-Zhong, YAO Wei-Xing, DAI Shui-Ping, JIANG Ming-Xing,HUANG Wen-Long, HUANG
Zhen-Ya, PENG Si-Xun.Effects of 7-chlor-benzyltetrahydropalmatine on delayed after depolarization,triggered activity
in guinea pig papillary muscle and monophasic action potential in cat heart[J].Chinese Journal of Pharmacology and Toxicology,1995(3). |
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| Authors: | XIA Guo-Jin ZENG Wei-Zhong YAO Wei-Xing DAI Shui-Ping JIANG Ming-Xing HUANG Wen-Long HUANG
Zhen-Ya PENG Si-Xun |
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| Abstract: | The study by usjng standardmicroelectrode techniq ues in guinea pig papillary muscle
in-dicated that ouabain-induced delayed a fter-depolariza tionand triggered acti vity were
abolished by 7-chlor-benzyl-tetrahydropalmatine(7-chlor-BTHP)50 μmol·L-1. Anoth-er study
showed that 7-chlor-BTHP prolonged monophasicAPD50 and APD90 from 222 ±20 and 314 ±
54 ms to 264±28 and 334 ± 54 ms(x±s, P< 0.05,n=5)respectivelyin normal myocardium of
cat.In the meantime,the short-ened APD induccd by iscbemia and reperfusion was res-stored to
normal level by 7-chlor-BTHP. 7-Chlor-BTHPdecreased monophasic action potential amplotude
and heartrate from 55 ± 7 mV and 62 ± 8 beats· min-1 to 44±10mV and 57 ± 9
beats·min-1(x±s, P<0. 05,n=5)respectively.It also decreased incidences of
vendcularfibrillation and mortality and could prothect againstmyocardial damagc caused by
ischemia and reperfusion. |
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| Keywords: | -chlor-benzyltetrahybropalmatine anti-arrhythmia agents papillary muscle action potential |
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