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| 3,6-(二甲氨基)-二苯并碘杂六环葡萄糖酸盐对大鼠心肌缺血的保护作用 | |
| 引用本文： | 李西宽,刘俊田,邓秀玲,苟伟,孙晓明,赵进,侯自杰.3,6-(二甲氨基)-二苯并碘杂六环葡萄糖酸盐对大鼠心肌缺血的保护作用[J].中国药理学与毒理学杂志,2001,15(3):172-175. |
| 作者姓名： | 李西宽 刘俊田 邓秀玲 苟伟 孙晓明 赵进 侯自杰 |
| 作者单位： | 1. 西安医科大学药理学教研室, 陕西西安 710061 2. 西安医科大学机能中心,陕西西安 710061 3. 兰州大学化学系, 甘肃兰州 730003 |
| 摘 要： | 采用结扎冠状动脉制备心肌缺血模型和iv垂体后叶素诱导心肌缺血模型 ,观察了 3,6 (二甲氨基 ) 二苯并碘杂六环葡萄糖酸盐 (IHC 93)对大鼠心肌损伤的影响 .结果表明 ,IHC 930 .2 5及 0 .50mg·kg- 1能够缩小大鼠缺血心肌的梗死范围 ;明显减少缺血心肌乳酸脱氢酶及肌酸磷酸激酶的释放 ;对抗结扎冠脉和iv垂体后叶素所致的心电图ST段 T波抬高 ;明显改善缺血心肌光镜下的细胞损伤 .结果提示 ,IHC 93对大鼠急性缺血心肌损伤有保护作用 . |
| 关 键 词： | 3 6-(二甲氨基)-二苯并碘杂六环葡萄糖酸盐 心肌 缺血 乳酸脱氢酶 肌酸磷酸激酶 |
| 收稿时间： | 2000-3-9 |
Protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemia in rats |
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| LI Xi-Kuan, LIU Jun-Tian, DENG Xiu-Ling, GOU Wei, SUN Xiao-Ming, ZHAO Jin, HOU Zi-Jie.Protective effect of 3,6-dimethamidodibenzopyriodonium gluconate on myocardial ischemia in rats[J].Chinese Journal of Pharmacology and Toxicology,2001,15(3):172-175. | |
| Authors: | LI Xi-Kuan LIU Jun-Tian DENG Xiu-Ling GOU Wei SUN Xiao-Ming ZHAO Jin HOU Zi-Jie |
| Institution: | LI Xi-Kuan1, LIU Jun-Tian1, DENG Xiu-Ling1, GOU Wei2, SUN Xiao-Ming2, ZHAO Jin2, HOU Zi-Jie3 |
| Abstract: | This paper described the effects of 3,6-dimethamidodibenzopyriodonium gluconate(IHC- 93) on the acute myocardial ischemia produced by the ligation of descending anterior branch of left coronary artery and pituitrin (0.5 U·kg-1, iv). The results showed that IHC 93 at the dose of 0.25 and 0.5 mg·kg-1 shrank the area of acute myocardial infarction, reduced lactate dehydrogenase and creatine phosphokinase level in serum. IHC-93 also reduced the abnormal changes in ECG and myocardial injury under the observation of light microscopes. It is suggested that IHC-93 exert significantly protective effect against myocardial ischemia in rats. |
| Keywords: | dimethamidodibenzopyriodoni um gluconate myocardium ischemia lactate dehydrogenase creatine phosphokinase |
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