| 马兜铃酸细胞分子毒理学研究进展 |
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| 引用本文： | 乔洪翔,李连达,吴理茂.马兜铃酸细胞分子毒理学研究进展[J].中国药理学与毒理学杂志,2006,20(6):515-520. |
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| 作者姓名： | 乔洪翔 李连达 吴理茂 |
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| 作者单位： | 浙江大学药学院中药研究所,浙江,杭州,310031 |
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| 摘 要： | 马兜铃酸属于硝基菲类化合物,广泛存在于马兜铃属中药中,具有肾毒性和潜在的致癌作用。马兜铃酸诱导肾小管上皮细胞纤维化及凋亡;促进细胞周期加速,而导致泌尿道上皮异常增殖;经还原代谢,并与DNA形成加合物,使ras基因和p53基因突变,进而诱发癌变。本文对马兜铃酸的细胞分子毒性机制进行了综述,并对可能的减毒方法进行了探讨。
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| 关 键 词： | 马兜铃酸 DNA加合物 毒理学 |
| 收稿时间： | 2006-02-08 |
| 修稿时间： | 2006-06-30 |
Molecular cellular toxicology of aristolochic acid and its advances |
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| QIAO Hong-Xiang,LI Lian-Da,WU Li-Mao.Molecular cellular toxicology of aristolochic acid and its advances[J].Chinese Journal of Pharmacology and Toxicology,2006,20(6):515-520. |
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| Authors: | QIAO Hong-Xiang LI Lian-Da WU Li-Mao |
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| Institution: | Institute of Chinese Herb Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China |
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| Abstract: | Aristolochic acid is a nitrophenanthrene derivative isolated from most of Aristolochia species and has been shown to be a nephrotoxicity and a potent carcinogen to both rats and human. Aristolochic acid induced transdifferentiation and apoptosis in human tubular epithelial cells, and induced proliferation anormally through cell cycle progression, and induced mutation in the ras and p53 genes by DNA adduct formation via reductive metabolism, and then induced cancer. In this paper, the underlying cellular and molecular mechanisms of toxicity of aristolochic acid and methods of attenuation are elucidated. |
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| Keywords: | aristolochic acid DNA adduct toxicology |
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