Effect of doxazosin on insulin sensitivity in hypertensive non-insulin dependent diabetic patients |
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Authors: | R Huupponen MD A Lehtonen M Vähätalo |
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Institution: | (1) Department of Clinical Pharmacology, University of Turku, Kiinamyllynkatu 10, SF-20520 Turku, Finland;(2) Department of Medicine, Turku City Hospital, Turku, Finland;(3) Turku City Health Centre, Turku, Finland |
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Abstract: | Summary The effect of doxazosin, an a,-adrenoceptor blocking drug, on blood pressure, sensitivity to insulin and serum lipids has been evaluated in 14 hypertensive, non-insulin dependent diabetic patients. The dose was titrated individually upwards from 1 mg until the diastolic blood pressure was below 90 mm Hg, side-effects precluded further dosage increase or the maximum daily dose of 16 mg was achieved.After 12 weeks of treatment (mean doxazosin dose 5.6 ± 5.1 mg daily), the supine and standing diastolic blood pressure of the patients had declined by about 7 mmHg, whereas their systolic blood pressure and heart rate were not significantly changed. The metabolic clearance rate of glucose increased from 2.35 to 3.37 ml - min–1 - kg–1 during treatment, suggesting improved sensitivity to insulin. Fasting plasma glucose was 11.9 mmol·1–1 before and 10.9 mmol·l–1 after doxazosin therapy (NS). Serum electrolytes and lipids did not change significantly but serum uric acid decreased from 305 to 281 mol · 1–1
Doxazosin may be a useful alternative for the treatment of hypertension in NIDDM patients. |
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Keywords: | Doxazosin Hypertension Diabetes mellitus non-insulin dependent diabetes mellitus insulin sensitivity serum lipids adverse drug effects |
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