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盐酸氨溴索治疗老年慢阻肺合并肺部感染的疗效
引用本文:张月莉,龚瑾,章亚萍,庞仲华.盐酸氨溴索治疗老年慢阻肺合并肺部感染的疗效[J].中国临床药学杂志,2001,10(4):224-227.
作者姓名:张月莉  龚瑾  章亚萍  庞仲华
作者单位:上海华东医院呼吸科
摘    要:目的:观察盐酸氨溴索对老年慢阻肺(COPD)合并急性肺部感染的临床疗效。方法:选择COPD合并急性肺部感染的男性患者65例,均有痰液粘稠,痰不易咳出至少1wk以上。A组40例,给予盐酸氨溴索针剂30mg加入5%GS100ml,iv,gtt,bid。B组25例,给予溴己新针剂16mg加入20ml0.9%NS中缓慢iv,bid,7-10d为一疗程,用药期间不用其他祛痰剂,可同时合用抗生素、支气管扩张剂等药。观察给药前后患者咳痰费力程度、咳嗽、痰的性状、痰量及肺部罗音的轻重程度。重点对咳痰难易程度进行疗效评定,并记录不良反应。结果:患者的咳嗽、咳痰、咳痰容易程度、痰性状及肺部罗音等方面均有不同程度的改善,其中以咳痰难易程度疗效最佳,有效率为100%。而咳嗽、痰量、痰的性状和肺部罗音的改善率分别为80%、60%、70%和90%。A组未见不良反应。结论:盐酸氨溴索针剂在老年COPD合并急性肺部感染患者的咳嗽和咳痰容易程度等方面明显优于溴己新,且不良反应小,是一种疗效好、安全可靠的化痰剂。

关 键 词:盐酸氨溴索  老年患者  慢性阻塞性肺疾病  肺部感染  COPD
文章编号:1007-4406(2001)04-0224-04

Efficacy of ambroxol hydrochloride therapy in elderly chronic obstructive pulmonary disease patients with acute pulmonary infection
Zhang Yueli,Gong Jin,Zhang Yaping,Pang Zhonghua.Efficacy of ambroxol hydrochloride therapy in elderly chronic obstructive pulmonary disease patients with acute pulmonary infection[J].Chinese Journal of Clinical Pharmacy,2001,10(4):224-227.
Authors:Zhang Yueli  Gong Jin  Zhang Yaping  Pang Zhonghua
Abstract:AIM: To investigate the clinical effects of ambroxol to treat elderly chronic obstructivepulmonary disease (COPD) patients with acute pulmonary infection. METHODS: sixty five elderly COPD patients with acute pulmonary infection were divided into 2 groups. Group A was give ambroxol 30 mg, diluted in 100 ml of GS, intravenously dripped twice a day. Group B was given bromhexine 16 mg diluted in 20 ml of normal saline (NS) intravenous twice a day, for 7 10 d. RESULTS: Administration of ambroxol exerted marked clinical effects as evidenced by improved cough, easy extend of expectoration, amount of sputum, sputum properties and pulmonary rale. The improvement rate of above symptoms in Group A were 80%, 60%, 70%, 90%, respectively. There were significantly improvement on cough, easy extend of expectoration and pulmonary rale in Group A, compared with that of Group B ( P <0 05). There was no significant difference on amount of sputum and sputum properties, between 2 Group. CONCLUSION: The results show that ambroxol is more effective than bromhexine on improving cough, easy extend of expectoration and pulmonary rale. Ambroxol is a useful and safe mucolytic agent.
Keywords:ambroxol hydrochloride  elderly patients  chronic obstructive pulmonary disease  pulmonary infection
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