川芎、当归萃取液对实验性急性脑梗死大鼠行为学和脑组织损伤的影响

目的：通过建立大鼠急性脑梗死模型。观察不同剂量的川芎，当归萑取液与阳性药物（尼莫地平）对大鼠急性脑梗死的行为和病理等影响。方法：各实验组大鼠在术后清醒（术后4h及28h)2次给药，并进行2次行为检查（术后4及52h)和第2次给药后24h(术后52h)进行大鼠脑组织病理切片检查。结果：给川芎，当归萃取液及阳性药物后的大鼠行为积分值明显低于对照组，且脑部病理损害程度明显轻于溶剂组，结论：川芎、当归萃取液对急性阻断大脑中动脉所致脑缺血造成大鼠行为障碍具有明显的缓解治疗作用。对大鼠中动脉阻断后脑缺血造成的脑部病理损害具有保护，减轻作用。

Effect of extract liquid of Ligusticum chuanxiong and Angelica sinensis on rat model of acute cerebral infarction

AIM: By setting up acute cerebral infarction (ACI) model in rats to study effects of the action and pathology in ACI rats for different doses of extract liquid of Ligusticum chuanxiong and Angelica sinensis and positive control medicine (nimodipine). METHODS: To observe actions (at 4 h and 52 h after operation) and examine sections of cerebral pathological issues (at 52 h after operation) in rats with administration of medicines (at 4 h and 28 h after operation). RESULTS: The integral value of actions for extract liquid of Ligusticum chuanxiong and Angelica sinensis group was lower significantly and degree of cerebral pathological injury lighter, compared with solvent control group. CONCLUSION: Extract liquid of Ligusticum chuanxiong and Angelica sinensis has obviously therapeutic effects on rats with action obstacle caused by cerebral ischemia after acute middle cerebral artery occlusion in rats and reduced pathological injuryed degree of cerebral issues.