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二甲双胍联合综合促排卵治疗多囊卵巢综合征的临床研究
引用本文:全启花,余琳,陈敦金,杨洁.二甲双胍联合综合促排卵治疗多囊卵巢综合征的临床研究[J].国际医药卫生导报,2009,15(10).
作者姓名:全启花  余琳  陈敦金  杨洁
作者单位:1. 高要市人民医院妇产科,526040
2. 广州医学院第三附属医院妇产科,广州市重症孕产妇救治中心
摘    要:目的 探讨二甲双胍联合氯米芬-促性腺激素在多囊卵巢综合征(PCOS)患者治疗中的临床疗效观察.方法 60例PCOS患者,试验组应用二甲双胍联合氯米芬-促性腺激素,对照组只应用CC-hMG/hCG促排卵,具体使用方法同观察组.两组各治疗一个周期.结果 两组治疗情况比较,观察组30例中,2例口服二甲双胍期间妊娠,28例促排卵治疗,有效27例,且均使用hCG诱发排卵,无反应1例;对照组促排卵治疗有效25例,1例因卵巢轻度刺激放弃hCG诱发排卵,无反应5例.有效病例中使用HMG治疗天数及用药剂量观察组分别(3.84±0.6)天和(7.84±1.8)支,对照组分别为(4.84±1.6)天和(9.34±2.7)支.两组比较差异有显著性(P<0.01).结论 二甲双胍联合氯米芬可有效地改善PCOS患者的胰岛素抵抗,降低血雄激素水平,诱导排卵,并恢复生育功能.

关 键 词:二甲双胍  多囊卵巢综合征  氯米芬

Clinical research of metformin combined ovulation therapy in women with polycystic ovsry syndrome
Abstract:Objective To investigate the clinical effects of metformin combined ovulation therapy on women with polycystie ovary syndrome(PCOS).Methods sixty-patients with PCOS were classified into 2 groups, the test group were treat by dimethyl biguanide and clomiphene and CC-hMG/hCG, the control group only used CC-hMG/hCG, all of them were be treated one cycle.Results there were 2 case had pregnancy during taking dimethyl biguanide orally. Effective case were 27, that is 27/28, and the time and the dose of use the CC-hMG/ hCG were (3.84±0.6)days and(7.84±1.8) rami individually, only one case were inefficacious.the control group had 25 effective case, and the time and the dose of use the CC-hMG/hCG were (4.84±1.6) days and (9.34±2.7) rami individually, there were significant difference between the two groups(P<0.05).Conclusion Metformin may effectively improve insulin resistance, reduce serum androgen level, and recover ovulation function in women with PCOS.
Keywords:polycystic ovary syndrome  metformin  clomiphene
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