亨氏小体和G6PD检测对地中海贫血筛查的应用价值

目的评价亨氏小体和葡萄糖6磷酸脱氢酶（G6PD）检测在地中海贫血筛查中的应用价值，为临床寻找一种更理想的地贫筛查的检验方法。方法在血红蛋白电泳、红细胞平均体积（MCV）、红细胞渗透脆性试验（脆性试验）的基础上增加亨氏小体和G6PD检测。结果用血红蛋白电泳、MCV、脆性试验联合检测对轻型α-地贫的准确度为90．5％，用Hh电泳、MCV、脆性试验、亨氏小体、G6PD对轻型α-地贫的准确度为96．8％，两项检测差异有显著性。结论血红蛋白电泳、MCV、脆性试验、亨氏小体、G6PD联合测定是地贫筛查的较理想的试验方法。

Value of detection of Heinz bodies and C6PD in screening of thalassemia

Objective To assess the value of combined detection of Heinz bodies and G6PD in screening of thalassemia. Methods Detection of Heinz bodies and G6PD were performed in addition to hemoglobin(Hb)electrophoresis and tests for mean corpuscular volume(MCV)and red cell osmotic fragility(RCOF). Results The accuracy of detecting α - thalassemia differed significantly between the combined test of Hb electrophoresis, MCV, and RCOF and the combined method of Hb electrophoresis, MCV, RCOF, Heinz bodies, and G6PD(90.5% vs. 96.8%). Conclusions Of Hb electrophoresis combined with tests for MCV, RCOF, Heinz bodies, and G6PD is a better method in screening of thalassemia.