痹祺胶囊联合洛索洛芬钠治疗类风湿性关节炎的临床研究

目的探讨痹祺胶囊联合洛索洛芬钠治疗类风湿性关节炎患者的临床效果。方法选取2015年3月—2018年3月天津医科大学总医院滨海医院和天津医院诊治类风湿性关节炎患者104例,根据患者用药差别分成对照组和治疗组,每组各52例。对照组患者口服洛索洛芬钠片,60 mg/次,3次/d。治疗组患者在对照组基础上口服痹祺胶囊,1.2 g/次,3次/d。两组患者连续治疗3个月。观察两组患者临床疗效,同时比较治疗前后两组患者压痛和肿胀关节数及症状积分,血清基质金属蛋白酶3(MMP-3)和骨特异性碱性磷酸酶(B-ALP)水平及红细胞沉降(ESR)。结果治疗后,对照组的总有效率为82.69%,显著低于治疗组的96.15%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者压痛关节数、肿胀关节数及症状积分较治疗前均显著减少(P0.05),且治疗组压痛关节数、肿胀关节数及症状积分明显少于对照组(P0.05)。治疗后,两组血清MMP-3水平、ESR均显著降低(P0.05),血清B-ALP水平显著升高(P0.05),且治疗组MMP-3、ESR和B-ALP水平明显好于对照组(P0.05)。结论痹祺胶囊联合洛索洛芬钠片治疗类风湿性关节炎能够显著改善患者临床症状和生化指标水平,安全性高,具有一定的临床推广应用价值。

Clinical study on Biqi Capsules combined with loxoprofen sodium in treatment of rheumatoid arthritis

Objective To investigate the clinical effects of Biqi Capsules combined with loxoprofen sodium in treatment of rheumatoid arthritis. Methods Patients (104 cases) with rheumatoid arthritis in Binhai Hospital of General Hospital of Tianjin Medical University and Tianjin Hospital from March 2015 to March 2018 were divided into control (43 cases) and treatment (43 cases) groups according to different treatments. Patients in the control group were po administered with Loxoprofen Sodium Tablets, 60 mg/time, three times daily. Patients in the treatment group were po administered with Biqi Capsules on the basis of the control group, 1.2 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the joints numbers of tender and swollen, and symptom scores, and serum MMP-3 and B-ALP levels, and ESR in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 82.69%, which was significantly lower than 96.15% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the joints numbers of tender and swollen, and symptom scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum MMP-3 levels and ESR in two groups were significantly decreased (P<0.05), but serum B-ALP levels were significantly increased (P<0.05), and the MMP-3, ESR and B-ALP levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Biqi Capsules combined with loxoprofen sodium in treatment of rheumatoid arthritis can significantly improve the clinical symptoms and the biochemical indicators with high safety, which has a certain clinical application value.