2017年中国医科大学附属盛京医院老年住院患者鲍曼不动杆菌的分布及耐药性分析

目的 对2017年中国医科大学附属盛京医院老年住院患者鲍曼不动杆菌的分布及耐药性进行分析，为临床治疗提供科学指导依据。方法 回顾性分析2017年中国医科大学附属盛京医院老年住院患者鲍曼不动杆菌的标本来源、科室分布及耐药情况。结果 共分离出鲍曼不动杆菌193株，其中165株（85.49%）为多重耐药鲍曼不动杆菌。痰液标本为鲍曼不动杆菌的主要来源。重症监护室、呼吸内科是多重耐药鲍曼不动杆菌分布最多的两个科室。多重耐药鲍曼不动杆菌对大部分抗菌药物严重耐药，其中对头孢唑林、头孢西丁、头孢替坦、头孢噻肟、哌拉西林/他唑巴坦、哌拉西林、呋喃妥因、氨曲南、氨苄西林、阿莫西林/克拉维酸、头孢呋辛、氯霉素、磷霉素、诺氟沙星的耐药率均为100.00%，对替加环素的耐药率最低，为8.50%；非多重耐药鲍曼不动杆菌对大部分抗菌药物敏感。结论 中国医科大学附属盛京医院老年住院患者多重耐药鲍曼不动杆菌感染情况严重，针对老年住院患者建立更加严密的监控机制，加强流行病学资料的采集及干预工作的开展具有重要实践价值。

Analysis on distribution and drug resistance of Acinetobacter baumannii in elderly inpatients in Shengjing Hospital of China Medical University in 2017

Objective To analyze the distribution and drug resistance of Acinetobacter baumannii in elderly inpatients in Shengjing Hospital of China Medical University in 2017, so as to provide scientific basis for clinical treatment. Methods Source distribution of specimens, department distribution, and drug resistance of A. baumannii in elderly inpatients in Shengjing Hospital of China Medical University in 2017 were analyze retrospectively. Results A total of 193 strains of A. baumannii were isolated, among which 165 strains (85.49%) were multiresistant A. baumannii (MDR-AB). The sputum samples were the main source. MDR-AB was mainly detected from Intesive Care Unit and Department of Respiratory. MDR-AB had high resistant rates against most antibiotics. The resistance rates of A. baumannii against cefazolin, cefoxitin, cefotetan, cefotaxime, piperacillin/tazobactam, piperacillin, macrodantin, aztreonam, ampicillin, amoxicillin/clavulanic acid, cefuroxime, chloromycetin, phosphonomycin, norfloxacin were 100.00%. The resistant rate A. baumannii against tegacycline was the lowest (8.50%). Non MDR-AB was sensitive against most antibiotics. Conclusion The MDR-AB infection in elderly inpatients is serious in Shengjing Hospital of China Medical University. Therefore, it is of great practical value to establish a more strict monitorring mechanism, collect epidemiological date, and carry out intervention for the elderly inpatients.