妇科千金片联合左氧氟沙星治疗慢性宫颈炎的临床研究

目的探究妇科千金片联合盐酸左氧氟沙星片治疗慢性宫颈炎的临床疗效。方法选取2015年11月—2016年11月广元市妇幼保健院妇产科收治的慢性宫颈炎患者155例,所有患者随机分为对照组(77例)和治疗组(78例)。对照组口服盐酸左氧氟沙星片,1片/次,3次/d。治疗组在对照组基础上口服妇科千金片,6片/次,3次/d。两组患者连续治疗14 d。观察两组的临床疗效,比较两组的宫颈糜烂、炎症因子和不良反应。结果治疗后,对照组和治疗组的总有效率分别为87.01%、97.44%,两组比较差异有统计学意义(P0.05)。治疗后,对照组和治疗组的宫颈糜烂恢复正常率分别为50.65%、69.23%,两组比较差异有统计学意义(P0.05)。治疗后,两组IL-2、IL-10和hs-CRP水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,对照组和治疗组的不良反应发生率分别为15.58%、3.85%,两组比较差异有统计学意义(P0.05)。结论妇科千金片联合盐酸左氧氟沙星片治疗慢性宫颈炎具有较好的临床疗效,能显著改善宫颈糜烂,调节炎症因子水平,安全性较好,具有一定的临床推广应用价值。

Clinical study on Fuke Qianjin Tablets combined with levofloxacin in treatment of chronic cervicitis

Objective To investigate the clinical efficacy of Fuke Qianjin Tablets combined with Levofloxacin Hydrochloride Tablets in treatment of chronic cervicitis. Methods Patients (155 cases) with chronic cervicitis in Maternal and Child Health Hospital of Guangyuan from November 2015 to November 2016 were randomly divided into the control group (77 cases) and the treatment group (78 cases). Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Fuke Qianjin Tablets on the basis of the control group, 6 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and cervical erosion, inflammatory factor, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.01% and 97.44%, respectively, and there was difference between two groups (P<0.05). After treatment, the recovery rate of cervical erosion in the control and treatment groups were 50.65% and 69.23%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of IL-2, IL-10, and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence rate of adverse reaction in the control and treatment groups were 72.5% and 92.5%, respectively, and there was difference between two groups (P<0.05). Conclusion Fuke Qianjin Tablets combined with Levofloxacin Hydrochloride Tablets has clinical curative effect in treatment of chronic cervicitis, can improve cervical erosion, and regulate inflammatory factor levels, with good safety, which has a certain clinical application value.