天麻素胶囊联合苯妥英钠治疗三叉神经痛的临床研究

目的 探讨天麻素胶囊联合苯妥英钠片治疗三叉神经痛的临床疗效.方法 选取2018年3月—2020年9月在驻马店市中心医院就诊的100例三叉神经痛患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各50例.对照组口服苯妥英钠片,100 mg/次,3次/d.治疗组在对照组的基础上口服天麻素胶囊,0.1 g/次,3次/d...

Clinical study on Gastrodin Capsules combined with phenytoin sodium in treatment of trigeminal neuralgia

Objective To investigate the clinical effect of Gastrodin Capsules combined with Phenytoin Sodium Tablets in treatment of trigeminal neuralgia. Methods Patients(100 cases) with trigeminal neuralgia in Zhumadian Central Hospital from March 2018 to September 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Phenytoin Sodium Tablets, 100 mg/time, three times daily. Patients in the treatment group were po administered with Gastrodin Capsules on the basis of the control group, 0.1 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptoms, VAS scores, the serum levels of 5-HT, β-EP, PGE2, and IL-1β in two groups were compared. Results After treatment, the total effective rates were 94.00% and 82.00% in the treatment group and control group, and the difference was statistically significant(P < 0.05). After treatment, the attack frequency and attack duration of two groups were significantly reduced, and the difference was statistically significant(P < 0.05). The attack frequency and attack duration of the treatment group were significantly lower than those of the control group, and the difference was statistically significant(P < 0.05). After treatment, the VAS scores of two groups were significantly decreased, and the difference was statistically significant(P < 0.05). And the VAS score of the treatment group was significantly lower than that of the control group, with a statistically significant difference(P < 0.05). After treatment, the levels of 5-HT, PGE2, IL-1β, in two groups were significantly decreased, but the levels of β-EP in two groups were significantly increased(P < 0.05). After treatment, the levels of 5-HT, PGE2, and IL-1β in the treatment group were lower than those in the control group, but the levels of β-EP in the treatment group were higher than that in the control group, and the difference was statistically significant(P < 0.05). Conclusion Gastrodin Capsules combined with Phenytoin Sodium Tablets can improve the clinical curative effect of trigeminal neuralgia, reduce the clinical symptoms and pain degree, regulate the secretion of neurotransmitters, and reduce the neuroinflammatory reaction.