试验用药品的冷链管理研究

厚朴酚及和厚朴酚是一对疏水性烯丙基联苯酚类结构的同分异构体，具有许多相同的药理作用，如抗炎、抗氧化、抗肿瘤、抗微生物等。厚朴酚及和厚朴酚是钙离子通道阻滞剂，能抑制胃肠道平滑肌收缩；也能促进胃动素和胃泌素分泌，增强胃肠道内Cajal间质细胞内质网上的三磷酸肌醇受体和兰尼碱受体的表达和受体活性，促进内质网释放钙离子，激活Cajal间质细胞的起搏电流，增强胃肠道的节律性收缩。因此。厚朴酚及和厚朴酚对胃排空和胃肠推进运动产生双向调节作用：当各种病理因子引起胃肠道运动功能低下时表现为促进胃排空和胃肠推进运动；当各种病理因子引起胃肠运动亢进时，表现为对抗亢进。加之它们的抗氧化和抗炎作用可保护肠黏膜免遭伤害，提高脓毒症所致的胃肠道运动障碍，也能对抗各种肠炎和泻药所致的腹泻。

Cold chain management for investigational drugs

Magnolol and honokiol are hydrophotic isomer of propenyl biphenol-type structure. They have many identical pharmacologic actions, including anti-inflammation, antioxidation, anticancer, anti-microbe. Magnolol and honokiol are Ca²⁺ channel blockers, to inhibit contraction of isoleted gastrointestinal smooth muscle. Magnolol and honokiol promote secretion of motilin and gastrin, and increase the expression and activity of IP3R and RyR on endoplasmic reticulum in gastrointestinal interstilial cells of Cajal to accelerate Ca²⁺ release from endoplasmic reticulum, and activate pacemaker currents of Cajal cells, and to enhance rhythmic contraction of gastrointestinal tract. Thus magnolol and honokiol have dual-directional regulation to gastric emptying and gastrointestinal propulsion movement, when various pathological factors induce hypofunction of gastrointestinal movement they show promoting gastric emptying and gastrointestinal propulsion, when various pathological factors induce hyperfunction of gastrointestinal movement they show antagonism. Additionally the antioxidation and anti-inflammation of magnolol and honokiol can induce the protection on intrstinal mucosa to improve sepsis-induced gastrointestinal motility disorders, and antagonize various enteritis- and cathartics-induced diarrhea.