丹参滴注液对慢性脑供血不足患者脑血液流变学与凝血功能的改善作用

目的 探讨丹参滴注液对慢性脑供血不足患者脑血液流变学与凝血功能的改善作用。方法 采用前瞻性、随机、对照研究方法，2015年10月—2017年12月选择西安大兴医院收治的脑供血不足患者130例，根据随机数字表法分为观察组与对照组各65例。对照组给予依达拉奉注射液30 mg加入0.9%氯化钠注射液100 mL中，静脉滴注，同时给予胞磷胆碱钠注射液0.5 g加入5%葡萄糖注射液250 mL中，静脉滴注，2次/d。观察组在对照组治疗的基础上给予丹参滴注液250 mL静脉滴注，1次/d，两组均治疗观察14 d。比较两组疗效及患者脑血液流变学和凝血功能的变化。结果 观察组与对照组的总有效率分别为96.9%和86.2%，观察组显著高于对照组，差异有统计学意义（P<0.05）。治疗后观察组的椎动脉与基底动脉血流速度分别为（33.29±7.35）cm/s和（33.59±8.14）cm/s，对照组分别为（30.22±8.02）cm/s和（30.78±7.19）cm/s，都显著高于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著高于对照组，差异有统计学意义（P<0.05）。观察组与对照组治疗后的聚集指数和纤维蛋白原都显著低于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后观察组的以上指标数值也显著低于对照组，差异有统计学意义（P<0.05）。结论 丹参滴注液辅助治疗慢性脑供血不足患者能改善脑血液流变学与凝血功能，从而提高治疗效果，对临床应用具有很好的指导意义。

Effects of Danshen Note drops on cerebral blood rheology and coagulation function in patients with chronic cerebral circulation insufficiency

Objective To investigate the effects of Danshen Note drops on cerebral blood rheology and coagulation function in patients with chronic cerebral circulation insufficiency. Methods From October 2015 to December 2017, Used a prospective, randomized, controlled study method, 130 cases of patients with chronic cerebral circulation insufficiency in our hospital were selected and were equally divided into the observation group and control group with 65 patients in each group accorded randomly. The control group was given routine treatment, the observation group was given Danshen note drops treatment on the basis of the control group, the treatment cycles in the two groups were 14 d.Results the total effective rates in the observation group and the control group were 96.9% and 86.2%, respectively, and the observation group was significantly higher than that of the control group (P<0.05). After treatment, the blood flow velocity of vertebral artery and basilar artery in the observation group were (33.29 ±7.35) cm/s and (33.59 ±8.14) cm/s, respectively, and the control group were (30.22 ±8.02) cm/s and (30.78 ±7.19) cm/s, respectively, which were significantly higher than those before treatment (P<0.05), and the observation group were significantly higher than that of the control group (P<0.05). The aggregation index and fibrinogen n the observation group and the control group were significantly lower than before treatment (P<0.05), and the index values after treatment in the observation group were significantly lower than that of the control group (P<0.05).Conclusion Danshen note drops in the treatment of patients with chronic cerebral circulation insufficiency can improve cerebral blood rheology and blood coagulation function, thereby improve the therapeutic effect, and it has a good guiding significance for clinical application.