| 雷公藤多苷肝毒性发生机制及减毒相关研究进展 |
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| 引用本文： | 罗岚,江振洲,张陆勇.雷公藤多苷肝毒性发生机制及减毒相关研究进展[J].现代药物与临床,2017,40(10):1504-1509. |
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| 作者姓名： | 罗岚 江振洲 张陆勇 |
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| 作者单位： | 中国药科大学 江苏省新药筛选重点实验室, 江苏 南京 210009,中国药科大学 江苏省新药筛选重点实验室, 江苏 南京 210009;中国药科大学 江苏省药效研究与评价服务中心, 江苏 南京 210009,中国药科大学 江苏省新药筛选重点实验室, 江苏 南京 210009;广东药科大学 药学院, 新药筛选与药效学评价中心, 广东 广州 510006 |
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| 基金项目： | 公益性行业科研专项（201507004-002）；国家重大新药创制专项（2015ZX09501004-002-004）；国家自然科学基金重大国际（地区）合作研究项目（No.81320108029） |
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| 摘 要： | 雷公藤多苷是一种从植物雷公藤中提取出的有效组分，具有免疫抑制、抗炎等作用，临床上多用于治疗风湿性关节炎和肾病综合征等。在雷公藤多苷众多不良反应中，其肝脏相关不良反应尤为显著。针对雷公藤多苷的肝毒性作用，总结近十年对雷公藤多苷肝毒性作用及机制的研究进展，并对其毒性物质基础进行了分析，对相应的配伍减毒药物以及其保护机制进行了总结分析，为雷公藤多苷的临床合理使用及配伍减毒提供文献和理论依据。
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| 关 键 词： | 雷公藤多苷 不良反应 肝毒性机制 物质基础 减毒药物 |
| 收稿时间： | 2017/4/20 0:00:00 |
Research progress of hepatotoxicity mechanism and attenuation of Tripterygium wilfordii glycoside |
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| LUO Lan,JIANG Zhen-zhou and ZHANG Lu-yong.Research progress of hepatotoxicity mechanism and attenuation of Tripterygium wilfordii glycoside[J].Drugs & Clinic,2017,40(10):1504-1509. |
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| Authors: | LUO Lan JIANG Zhen-zhou and ZHANG Lu-yong |
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| Institution: | Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China,Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;Center for Drug Screening and Pharmacodynamics Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China |
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| Abstract: | Tripterygium wilfordii glycoside is an effective component extracted from Tripterygium wilfordii Hook. F. It has an effect on immunosuppression and anti-inflammatory which is used to treatments of rheumatic arthritis and nephrotic syndrome on clinic. The liver adverse reactions have been particularly significant in Tripterygium wilfordii glycoside induced adverse reactions. The aim of this article is to summarize the research of hepatotoxicity mechanism of Tripterygium wilfordii glycoside in recent ten years, to analyze toxic material base, and to search for the attenuated drugs and mechanism. For the clinical application of Tripterygium wilfordii glycoside this article provides related literature and theoretical basis research. |
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| Keywords: | Tripterygium wilfordii glycoside adverse reaction hepatotoxicity mechanism material base attenuated drug |
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