女贞子及其活性成分的骨骼肌药理作用研究进展

女贞子及其活性成分熊果酸、红景天苷等具有胰岛素样作用,对骨骼肌产生正性作用,即促进骨骼肌利用糖和脂质,增强肌糖原和肌蛋白合成,增加骨骼肌质量、快肌纤维和慢肌纤维体积,并促进快肌纤维向慢肌纤维转化。熊果酸还能刺激肌卫星细胞增殖、成肌细胞肌性分化,促进骨骼肌中新的肌细胞生长,促使骨骼肌强壮。其次,女贞子及其活性成分下调骨骼肌特异性的肌肉萎缩素-1和肌肉环状指蛋白表达,及其抗氧化应激和抗炎作用,最终可以防治肌萎缩和疲劳引起的骨骼肌损伤。

Research advances on pharmacologic effects of Ligustri Lucidi Fructus and its active constituents in skeletal muscle

Ligustri Lucidi Fructus and its active constituents, ursolic acid and salidroside, have insulin-like effect to produce positive action on skeletal muscle:, It can improve the utilization of carbohydrate and lipid in muscle, increase synthesis of muscular glycogen and protein, muscular weigh, size of fast-and slow-muscle fibers, and accelerate transformation fast-muscle fiber toward slow-muscle fiber. Ursolic acid stimulates muscle satellite cells proliferation, myogenic differentiation of myoblasts, enhances neomyogenesis in skeletal muscle, and promotes skeletal muscle rejuvenation. In addition, Ligustri Lucidi Fructus and its active constituents down-regulating repression of atrogin-1 and muscle ring-finger protein-1 (MuRF-1), and anti-oxidation and anti-inflammation, it may protect and treat for muscle atrophy and fatigue-induced muscle injury.