| 熊果酸的药动学研究进展 |
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| 引用本文： | 张明发,沈雅琴.熊果酸的药动学研究进展[J].现代药物与临床,2018,41(1):169-173. |
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| 作者姓名： | 张明发 沈雅琴 |
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| 作者单位： | 上海美优制药有限公司, 上海 201422,上海美优制药有限公司, 上海 201422 |
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| 摘 要： | 熊果酸具有广泛的药理作用，包括抗炎、抗变态反应，抗肿瘤，保护心、血管、肝、肾、肺，抗糖尿病、调血脂抗肥胖，抗动脉粥样硬化等。但是其口服的生物利用度低，通过被动扩散被肠道吸收；将熊果酸制成分散体制剂能提高溶出度和生物利用度，且能浓集于肝脏，有利于治疗肝部疾病。综述熊果酸的药动学参数、体内过程和熊果酸分散体的药动学特征，总结其药动学研究进展，为合理用药提供参考。
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| 关 键 词： | 熊果酸 药动学 药理作用 合理用药 |
| 收稿时间： | 2017/10/21 0:00:00 |
Research advance on pharmacokinetics of ursolic acid |
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| ZHANG Ming-fa and SHEN Ya-qin.Research advance on pharmacokinetics of ursolic acid[J].Drugs & Clinic,2018,41(1):169-173. |
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| Authors: | ZHANG Ming-fa and SHEN Ya-qin |
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| Institution: | Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201422, China and Shanghai Meiyou Pharmaceutical Co. Ltd., Shanghai 201422, China |
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| Abstract: | Ursolic acid has a widespread pharmacologic effect, including anti-inflammation, anti-allergy, antitumor, protection of heart, blood vessel, liver, kidney, lung, antidiabetes, lipidemic regulation and anti-obesity, antiatherosclerosis, anti-hepatic steatosis and fibrosis, etc. Bioavailability of ursolic acid by oral administration is low since it is absorbed by intestine through passive diffusion. Ursolic acid dispersion preparation can increase its solubility and bioavailability, and concentrate on liver to help treat for hepatic disease. In this paper, the pharmacokinetic parameters, the process of ursolic acid in vivo, and the pharmacokinetic feature of ursolic acid dispersion are reviewed, and its research advance on pharmacokinetics is summarized, in order to provide a reference for rational utilization of ursolic acid. |
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| Keywords: | ursolic acid pharmacokinetics pharmacologic effect rational use of drug |
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