肾炎康复片联合环孢素A治疗难治性肾病综合征的临床研究

目的观察肾炎康复片联合环孢素软胶囊治疗难治性肾病综合征的临床疗效。方法选取2017年3月—2018年2月三二〇一医院收治的64例难治性肾病综合征患者作为研究对象,所有患者随机分为对照组和治疗组,每组各32例。对照组患者口服环孢素软胶囊,常用剂量为3 mg/(kg·d),分两次服用。治疗组在对照组治疗的基础上口服肾炎康复片,1片/次,3次/d。两组患者连续治疗6个月。观察两组患者的临床疗效,比较两组的血肌酐、血浆白蛋白、24 h尿蛋白水平和不良反应发生情况。结果治疗后,对照组和治疗组的总有效率分别为78.13%、93.75%,两组比较差异具有统计学意义(P0.05)。治疗后,两组血肌酐、血浆白蛋白、24 h尿蛋白均显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后治疗组血肌酐、血浆白蛋白、24 h尿蛋白明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗后,治疗组的不良反应发生率为18.7%,显著低于对照组的37.5%,两组比较差异具有统计学意义(P0.05)。结论肾炎康复片联合环孢素软胶囊治疗难治性肾病综合征的疗效显著,可改善患者肾功能,且不良反应少,具有一定的临床推广应用价值。

Clinical study on Shenyan Kangfu Tablets combined with cyclosporine A in treatment of refractory nephrotic syndrome

Objective To observe the clinical efficacy of Shenyan Kangfu Tablets combined with Cyclosporin Soft Capsules in treatment of refractory nephrotic syndrome.Methods Patients (64 cases) with refractory nephrotic syndrome in San Er Ling Yi Hospital from March 2017 to February 2018 were randomly divided into control and treatment groups, and each group had 32 cases. Patients in the control group were po administered with Cyclosporin Soft Capsules, the commonly used dose was 3 mg/(kg·d), and took it twice. Patients in the treatment group were po administered with Shenyan Kangfu Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and the levels of serum creatinine, plasma albumin, and 24 h urine protein, and the adverse reaction in two groups before and after treatment were compared.Results After treatment, the clinical efficacy in the control and treatment groups was 78.13% and 93.75%, respectively, and there were differences between two groups (P<0.05). After treatment, the levels of serum creatinine, plasma albumin, and 24 h urine protein in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, the levels of serum creatinine, plasma albumin, and 24 h urine protein in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, the incidence of adverse reactions in the treatment group was 18.7%, which was significantly lower than 37.5% in the control group, with significant difference between two groups (P<0.05).Conclusion Shenyan Kangfu Tablets combined with Cyclosporin Soft Capsules has significant efficacy in treatment of refractory nephrotic syndrome, can improve the renal function with less adverse reactions, which has a certain clinical application value.