| 双氢青蒿素诱导肿瘤细胞凋亡的信号通路研究进展 |
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| 引用本文： | 梁小娜,单淇,周福军,徐旭,侯文彬.双氢青蒿素诱导肿瘤细胞凋亡的信号通路研究进展[J].现代药物与临床,2019,42(4):775-780. |
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| 作者姓名： | 梁小娜 单淇 周福军 徐旭 侯文彬 |
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| 作者单位： | 天津中医药大学, 天津 300193,天津药物研究院, 天津 300193;中药现代制剂与质量控制国家地方联合工程实验室, 天津 300193;天津市质量标志物重点实验室, 天津 300193,天津药物研究院, 天津 300193;中药现代制剂与质量控制国家地方联合工程实验室, 天津 300193;天津市质量标志物重点实验室, 天津 300193,天津药物研究院, 天津 300193;天津市质量标志物重点实验室, 天津 300193;释药技术与药代动力学国家重点实验室, 天津 300193,天津药物研究院, 天津 300193;中药现代制剂与质量控制国家地方联合工程实验室, 天津 300193;天津市质量标志物重点实验室, 天津 300193 |
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| 基金项目： | 国家新药创制项目（2017ZX09101002-001-005） |
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| 摘 要： | 双氢青蒿素作为青蒿素的重要衍生物，是我国自行研制出的抗疟新药。近些年来，人们对双氢青蒿素进行了多方面的研究，在抗肿瘤研究方面有许多新进展，发现其诱导肿瘤细胞凋亡的机制与多条信号通路有关，例如PI3K/Akt、MAPK、STAT3、Wnt/β-catenin、NF-κB等信号通路。通过对作用机制的深入研究和阐述有望发现双氢青蒿素的新适应症，使其在临床上的应用更加广泛。
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| 关 键 词： | 双氢青蒿素 肿瘤 细胞凋亡 信号通路 |
| 收稿时间： | 2018/11/7 0:00:00 |
Progress in signaling pathways induced by dihydroartemisinin on tumor cell apoptosis |
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| LIANG Xiaon,SHAN Qi,ZHOU Fujun,XU Xu and HOU Wenbin.Progress in signaling pathways induced by dihydroartemisinin on tumor cell apoptosis[J].Drugs & Clinic,2019,42(4):775-780. |
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| Authors: | LIANG Xiaon SHAN Qi ZHOU Fujun XU Xu and HOU Wenbin |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin Pharmaceutical Research Institute, Tianjin 300193, China;State Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin 300193, China;Tianjin Key Laboratory of Quality Markers for Traditional Chinese Medicine, Tianjin 300193, China,Tianjin Pharmaceutical Research Institute, Tianjin 300193, China;State Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin 300193, China;Tianjin Key Laboratory of Quality Markers for Traditional Chinese Medicine, Tianjin 300193, China,Tianjin Pharmaceutical Research Institute, Tianjin 300193, China;Tianjin Key Laboratory of Quality Markers for Traditional Chinese Medicine, Tianjin 300193, China;National and Local Joint Engineering Laboratory for Modern Preparation and Quality Control of Traditional Chinese Medicine, Tianjin 300193, China and Tianjin Pharmaceutical Research Institute, Tianjin 300193, China;State Key Laboratory of Drug Release Technology and Pharmacokinetics, Tianjin 300193, China;Tianjin Key Laboratory of Quality Markers for Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | dihydroartemisinin tumor apoptosis signaling pathway |
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