玉屏风颗粒联合多索茶碱治疗儿童喘息性支气管炎的临床研究

目的探讨玉屏风颗粒联合多索茶碱治疗儿童喘息性支气管炎的临床效果。方法选择竹山县人民医院2016年1月—2017年3月收治的喘息性支气管炎患儿108例,随机分成对照组(54例)与治疗组(54例)。对照组患儿静脉滴注注射用多索茶碱,4 mg/kg加入5%葡萄糖注射液50 m L,1次/d。治疗组在对照组的基础上口服玉屏风颗粒,1袋/次,3次/d。两组患儿均连续治疗14 d。观察两组患儿临床疗效,比较治疗前后两组患儿症状体征消失时间和住院时间及免疫功能和治疗后3、6个月复发率。结果治疗后,对照组临床总有效率为77.78%,显著低于治疗组的96.30%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组症状体征消失时间和住院时间均比对照组明显缩短,两组比较差异具有统计学意义(P0.05)。治疗后,两组Ig E明显降低,CD~(4+)、CD~(4+)/CD~(8+)明显升高,治疗组CD~(8+)明显下降,同组比较差异具有统计学意义(P0.05),且治疗组免疫功能均明显优于对照组(P0.05)。治疗3、6个月后,治疗组复发率分别为1.85%、3.70%,均明显低于同期对照组的20.37%、25.93%,两组比较差异具有统计学意义(P0.05)。结论玉屏风颗粒联合多索茶碱治疗儿童喘息性支气管炎能有效促进症状体征的缓解,提高患儿的免疫功能,具有一定的临床推广应用价值。

Clinical study on Yupingfeng Granules combined with doxofylline in treatment of asthmatic bronchitis in children

Objective To investigate the clinical effect of Yupingfeng Granules combined with doxofylline in treatment of asthmatic bronchitis in children. Methods Children (108 cases) with asthmatic bronchitis in Zhushan People''s Hospital from January 2016 to March 2017 were randomly divided into control (54 cases) and treatment (54 cases) groups. Children in the control group were iv administered with Doxofylline for injection, 4 mg/kg added into 5% glucose solution 50 mL, once daily. Children in the treatment group were po administered with Yupingfeng Granules on the basis of the control group, 1 bag/time, three times daily. Children in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of symptoms and signs, hospitalization time, immune function, and the recurrence rate at 3 and 6 months in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 77.78%, which was significantly lower than 96.30% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of symptoms and signs, hospitalization time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the IgE level in two groups was significantly decreased, but CD⁴⁺ and CD⁴⁺/CD⁸⁺ in two groups were significantly increased, CD⁸⁺ in the treatment group was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the immune function in the treatment group was significantly better than that in the control group (P < 0.05). After treatment, the recurrence rate at 3 and 6 months in the treatment group were 1.85% and 3.70%, which were significantly lower than 20.37% and 25.93% in the control group, respectively, and there were differences between two groups (P < 0.05). Conclusion Yupingfeng Granules combined with doxofylline in treatment of asthmatic bronchitis in children can effectively promote the remission of symptoms and signs and improve the immune function, which has a certain clinical application value.