止血祛瘀明目片联合卵磷脂络合碘治疗视网膜中央静脉阻塞的临床研究

目的探讨止血祛瘀明目片联合卵磷脂络合碘治疗视网膜中央静脉阻塞(CRVO)的临床疗效。方法收集2014年8月—2016年1月在柳州市红十字会医院接受治疗的76例CRVO患者,根据治疗方案的差别分为对照组(38例)和治疗组(38例)。所有患者均进行常规基础治疗。对照组口服卵磷脂络合碘片,1片/次,3次/d。治疗组在对照组基础上口服止血祛瘀明目片,5片/次,3次/d。两组患者均连续治疗3个月。观察两组患者治疗前后临床疗效,同时比较两组患者治疗前后视力、血管内皮生长因子(VEGF)、内皮素-1(ET-1)和NO水平的变化。结果治疗后,治疗组总有效率为94.74%,显著高于对照组的78.95%,两组比较差异具有统计学意义(P0.05)。治疗后两组患者视力水平较治疗前均显著提高(P0.05),且治疗组视力水平改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后两组患者的VEGF和ET-1水平较治疗前显著降低,NO水平显著升高(P0.05),且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论止血祛瘀明目片联合卵磷脂络合碘治疗CRVO效果显著,可明显提高患者视力,改善机体细胞因子水平,具有一定的临床推广应用价值。

Clinical study on Zhixue Quyu Mingmu Tablets combined with iodized lecithin in treatment of central retinal vein occlusion

Objective To explore the clinical effect of Zhixue Quyu Mingmu Tablets combined with iodized lecithin in treatment of central retinal vein occlusion. Methods Patients (76 cases) with CRVO in Liuzhou Red Cross Hospital from August 2014 to Janurary 2016 were divided into control group (38 cases) and treatment group (38 cases) according to the different treatments. All patients were given conventional basic treatment. The patients in the control group were po administered with Iodized Lecithin Tablets, 1 tablet/time, three times daily. The patients in the treatment group were po administered with Zhixue Quyu Mingmu Tablets on the basis of the control group, 5 tablets/time, three times daily. The patients in two groups were treated for 3 months. After treatment, clinical effect was evaluated. In the same time, the visual acuity, VEGF, ET-1, and NO levels in two groups before and after treatment were compared. Results After treatment, clinical effect in the treatment groups was 94.74% which was significantly higher than that (78.95%) of the control group, and there were significant differences between two groups (P<0.05). After treatment, visual acuities in two groups were obviously increased (P<0.05). And the improvement degree of visual acuity in the treatment group was better than that in the control group, with significant difference between two groups (P<0.05). After treatment, levels of VEGF and ET-1 in two groups were significantly decreased (P<0.05), but levels of NO were obviously increased (P<0.05), and these observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zhixue Quyu Mingmu Tablets combined with iodized lecithin in treatment of CRVO has a significant clinical effect, and can improve the visual acuity and the levels of cytokines, which has a certain clinical application value.