生脉散超微粉的显微特征和溶出度研究 |
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引用本文: | 李守信,张则平,邱新建,贺凤成,苏瑞强,赵志全.生脉散超微粉的显微特征和溶出度研究[J].现代药物与临床,2013,28(2):175-178. |
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作者姓名: | 李守信 张则平 邱新建 贺凤成 苏瑞强 赵志全 |
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作者单位: | 鲁南制药集团股份有限公司,山东临沂276006;中药制药共性技术国家重点实验室,山东临沂276006 |
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基金项目: | 国家重点基础研究发展计划(973计划)项目 |
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摘 要: | 目的 研究生脉散超微粉的显微特征和溶出度差异,为生脉超微粉应用提供实验依据.方法 采用光学显微镜观察颗粒显微结构;电镜扫描观察微观形貌;以五味子甲素和五味子乙素为指标,采用HPLC法测定生脉散细粉和超微粉在不同时间溶出的量,计算累积溶出度.结果 生脉散经超微粉碎后,基本无完整细胞存在,粒度均匀;生脉散超微粉中五味子甲素和五味子乙素溶出速率高于细粉,但是180 min后累积溶出量没有明显差异.结论 超微粉碎可使生脉散显微特征变化明显,化学成分五味子甲素和五味子乙素溶出速率加快.
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关 键 词: | 生脉散 超微粉 显微特征 五味子甲素 五味子乙素 溶出度 |
Micro-characteristic and dissolution of ultra-micro Shengmai Powder |
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Abstract: | Objective To study the micro-characteristic and dissolution of ultra-micro powder in Shengmai Powder, and to provide experimental foundation for the application of ultra-micro powder in Shengmai Powder. Methods The microstructure was observed by light microscope and the micro shape was observed by .electron microscope scanning. The dissolutions of Shengmai Powder and ultra-micro powder in Shengmai Powder at different time were determined by HPLC using schizandrins A and B as indexes. Results Compared with the common powder, the cellules of ultra-micro powder were pulverized, and the particles were tiny without intact cells and uniform. The cumulative dissolution rates of schizandrins A and B in ultra-micro powder were higher than those in the traditional common powder, but there was no significant difference after 180 min. Conclusion The micro-characteristic of ultra-micro powder in Shengmai Powder is obviously changed after ultrafine grinding, and the dissolution velocity of schizandrins A and B increases. |
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Keywords: | Shengmai Powder ultra-micro powder micro-characteristics schizandrin A schizandrin B dissolution |
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