吸入制剂的研究进展

吸入给药是防治哮喘、慢性阻塞性肺疾病等呼吸道疾病的首选给药方式.常见的吸入给药制剂包括压力定量吸入剂、干粉吸入剂和雾化吸入剂.吸入给药有效的评价指标为粒径的测定,测定吸入制剂粒径的方法主要有撞击器法和光学仪器法.就目前吸入给药制剂的优点、剂型分类、体外评价和研究现状等进行综述.

Research progress in inhalation preparation

Inhalation administration is the first choice for the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary diseases (COPD). In clinic, the most common used dosage forms for inhaled drug administration are pressurized metered-dose inhalation, dry powder inhalation, and atomizing inhalation. The in vitro effective evaluation index of inhalation is particle size, and the determination of particle size could be carried out with the impactors method and the optical instruments method. This review discusses the characteristic, classification, research status, and in vitro evaluation methods of inhalation preparation.