左卡尼汀注射液对阿霉素所致心肌细胞损伤的保护作用

目的 观察左卡尼汀注射液对阿霉素所致的心肌细胞损伤的保护作用.方法 将培养5d的新生Wistar乳鼠心肌细胞随机分为正常对照组、阿霉素1 μg/mL阳性对照组和左卡尼汀10、20、30μg/mL保护组,加药后继续培养24 h,测定细胞存活率、乳酸脱氢酶(LDH)释放量、超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量.结果 左卡尼汀能显著提高受损心肌细胞的存活率,抑制LDH释放量,减少MDA的生成,提高SOD活性.结论 左卡尼汀对阿霉素所致的心肌细胞损伤具有保护作用.

Protection of Levocarnitine Injection on myocardial cell injury induced by adriamycin

Objective To study the antitussive, apophlegmatic, and anti-asthmatic effects of the extract from Hylocerei Undati Flos (EHUF). Methods The antitussive, apophlegmatic, and anti-asthmatic effects of EHUF were observed using cough-inducing, eliminating phlegm, and asthma-inducing mouse models. Normal mice were randomly divided into control, positive control, low-, mid-, and high-dose EHUF groups. Results Compared with the control group, high-, mid-, and low-dose of two types of EHUF could decrease the cough rate significantly in mice induced by ammonia solution (P < 0.05, 0.01); Aqueous EHUF and alcohol EHUF in mid- and high-dose could increase the excretion of phenolsulfonphthalein significantly in the respiratory tract of mice (P < 0.05, 0.01); Aqueous EHUF and alcohol EHUF in high-dose could also prolong the asthma latency period resulted from citric acid in guinea pigs significantly (P < 0.05). Conclusion The EHUF has significant antitussive, apophlegmatic, and anti-asthmatic effects.