滴通鼻炎水喷雾剂治疗变应性鼻炎的临床研究

目的 评价滴通鼻炎水喷雾剂治疗变应性鼻炎(鼻鼽)的临床疗效和安全性.方法采用随机、盲法、安慰剂平行对照、多中心临床研究,88例变应性鼻炎患者分为试验组66例、对照组22例,分别使用滴通鼻炎水喷雾剂和安慰剂,外用喷鼻,每次2揿(0.13 mL/揿),4次/d,疗程14 d.用变应性鼻炎临床疗效、鼻塞缓解时间、鼻塞缓解维持...

Clinical study on Ditong Biyanshui Spray for treatment of allergic rhinitis

Objective To evaluate the clinical efficacy and safety of Ditong Biyanshui Spray for the treatment of allergic rhinitis (Biqiu). Methods A randomized, blinded, placebo controlled, and multicenter trial method was used in this assay. The trial enrolled 88 patients with allergic rhinitis, including 66 cases in experimental group and 22 cases in control group, respectively given Ditong Biyanshui Spray and placebo for external application, pressing 2 once ( 0.13 mL/press ), 4 times/d, using 14 d as a course of treatment. Allergic rhinitis criteria of clinical curative effect, the time for easing stuffy nose and duration, and the number of sneeze were used to assess the efficacy. The general physical examination and adverse events were for assessment in safety. Results The clinical control rate, significant effective rate, effective rate, and ineffective rate were 13.64%, 46.97%, 30.30%, and 9.09% in the experimental group, and 0.00%, 13.64%, 27.27%, and 59.09% in the control group, respectively. Besides nasal congestion relieving duration and the number of sneezes, the overall results showed that the experimental group was superior to the control group with statistical significance (P<0.05). In addition, there were no adverse events in both two groups. Conclusion Ditong Biyanshui Spray is an effective clinical drug for the treatment of allergic rhinitis, as well as a secure drug.