| 克拉生坦 |
| |
| 引用本文： | 吕超君,谭初兵,周植星,张大同,徐为人.克拉生坦[J].现代药物与临床,2011,26(1):68-71. |
| |
| 作者姓名： | 吕超君 谭初兵 周植星 张大同 徐为人 |
| |
| 作者单位： | 天津药物研究院天津市新药设计与发现重点实验室;天津中医药大学中药学院;山东轻工业学院化工学院 |
| |
| 摘 要： | 脑血管痉挛(cerebral vasospasm,CVS)是蛛网膜下腔出血(subarachnoid hemorrhage,SAH)最常见的高危并发症之一,是SAH患者致死和致残的主要原因.有证据表明,内皮素信号系统在SAH后CVS和迟发性脑缺血损伤的病理生理过程中起重要作用,因而内皮素受体拮抗剂在CVS治疗中的意义备...
|
| 关 键 词： | 克拉生坦 蛛网膜下腔出血 脑血管痉孪 内皮素受体 内皮素受体拮抗剂 |
Clazosentan |
| |
| LV Chao-jun,TAN Chu-bing,ZHOU Zhi-xing,ZHANG Da-tong and XU Wei-ren.Clazosentan[J].Drugs & Clinic,2011,26(1):68-71. |
| |
| Authors: | LV Chao-jun TAN Chu-bing ZHOU Zhi-xing ZHANG Da-tong and XU Wei-ren |
| |
| Institution: | 1.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 3.School of Chemical Engineering,Shandong Institute of Light Industry,Jinan 250353,China |
| |
| Abstract: | Abstract: Cerebral vasospasm (CVS) is one of the most common complications with high risk following subarachnoid hemorrhage (SAH), and a leading cause of death and disability in SAH patients. There are evidences shown that endothelin pathways play key roles in the CVS following SAH and late cerebral ischemic injury, thus the therapeutic significance of endothelin receptor antagonists in CVS attract widely attention. Clazosentan, a selective endothelin receptor antagonist, has been proved to be effective for SAH-induced CVS in animal experiments and clinical trials. It is expected to become a new drug for treatment of CVS. |
| |
| Keywords: | Clazosentan subarachnoid hemorrhage cerebral vasospasm endothelin receptor endothelin receptor antagonist |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
|
