保胎灵胶囊联合烯丙雌醇治疗习惯性流产的临床研究

目的探讨保胎灵胶囊联合烯丙雌醇治疗习惯性流产的临床效果。方法选取2015年3月—2019年3月郑州市第六人民医院收治的80例习惯性流产患者,随机分成对照组(n=40)和治疗组(n=40)。对照组口服烯丙雌醇片,2片/次,1次/d。治疗组在对照组基础上口服保胎灵胶囊,3粒/次,3次/d。两组均于确定妊娠后开始服药,连服12周。观察两组的临床疗效和典型表现的消失时间,比较两组血清生殖激素、外周血T淋巴细胞亚群的变化情况。结果治疗后,对照组和治疗组的总有效率分别是75.0%、92.5%,两组比较差异有统计学意义(P<0.05)。治疗组典型表现(如腰酸、下腹坠胀、腹痛、阴道流血等)的消失时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组雌二醇(E2)、人绒毛膜促性腺激素β(β-HCG)、孕酮(P)水平均显著高于治疗前(P<0.05);治疗后,治疗组E2、β-HCG、P水平高于对照组,两组比较差异有统计学意义(P<0.05)。与治疗前相比,两组治疗后卵巢及子宫动脉的搏动、阻力指数(PI和RI)均显著降低(P<0.05);且治疗后,治疗组以上盆腔血流动力学参数值均显著低于对照组同期(P<0.05)。治疗后,两组外周血CD4^+、CD4^+/CD8^+较治疗前均显著下降(P<0.05);治疗后,治疗组CD4^+、CD4^+/CD8^+显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论保胎灵胶囊联合烯丙雌醇治疗习惯性流产有较好的临床疗效,能有效缓解患者的临床症状,升高体内生殖激素水平,改善卵巢及子宫动脉血流的高阻状态,纠正T淋巴细胞亚群的免疫失衡,具有一定的临床推广应用价值。

Clinical study on Baotailing Capsules combined with allylestrenol in treatment of habitual abortion

Objective To investigate the clinical effect of Baotailing Capsules combined with allylestrenol in treatment of habitual abortion.Methods 80 Patients with habitual abortion admitted to Zhengzhou Sixth People’s Hospital from March 2015 to March 2019 were selected and randomly divided into control group(n=40)and treatment group(n=40).Patients in the control group were po administered with Allylestrenol Tablets,2 tablets/time,once daily.Patients in the treatment group were po administered with Baotailing Capsules on the basis of the control group,3 grains/time,three times daily.Both groups began taking the drugs after confirmed pregnancy for 12 weeks.The clinical efficacy and typical disappearance time of the two groups were observed,and the changes of serum reproductive hormones and peripheral blood T lymphocyte subsets in the two groups were compared.Results After treatment,the total effective rates of the control group and the treatment group were 75.0%and 92.5%,respectively,and there were differences between two groups(P<0.05).The disappearance time of typical manifestations(such as lumbar acid,abdominal distension,abdominal pain,vaginal bleeding)in the treatment group was significantly shorter than that in the control group,and there were differences between two groups(P<0.05).The levels of E2,β-HCG and P in the two groups were significantly higher than those before treatment(P<0.05).After treatment,E2,β-HCG and P in the treatment group were higher than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Compared with before treatment,pulsation and resistance index(PI and RI)of ovarian and uterine arteries were significantly reduced after treatment in both groups(P<0.05).After treatment,pelvic hemodynamic parameters in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,CD4^+and CD4^+/CD8^+in peripheral blood of both groups decreased significantly compared with that before treatment(P<0.05).After treatment,CD4^+and CD4^+/CD8^+in the treatment group were significantly lower than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion Baotailing Capsules combined with allylestrenol has good clinical effect in treatment of habitual abortion,and can effectively relieve the clinical symptoms of patients,and can increase the level of reproductive hormones in the body,and also can improve the high resistance state of ovarian and uterine artery blood flow,and correct the immune imbalance of T lymphocyte subgroup,which has a certain clinical application value.