固肾安胎丸联合烯丙雌醇治疗先兆流产的临床研究

目的探讨固肾安胎丸联合烯丙雌醇治疗先兆流产的临床效果。方法选取2016年6月—2018年12月天津市东丽区东丽医院收治的例先兆流产患者120,随机分成对照组(60例)和治疗组(60例)。对照组口服烯丙雌醇片,1片/次,3次/d。治疗组在对照组基础上口服固肾安胎丸,1袋/次,3次/d。两组连续治疗14d。观察两组患者临床疗效,同时比较治疗前后两组患者主症缓解时间,血清孕酮(P)、人绒毛膜促性腺激素β-亚基(β-HCG)、糖类抗原125(CA125)、妊娠相关血浆蛋白A(PAPP-A)和血管内皮生长因子(VEGF)水平,子宫螺旋动脉血流动力学参数。结果治疗后,对照组临床有效率为75.00%,显著低于治疗组的90.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组阴道出血、腰酸胀痛及下腹坠痛的缓解时间均显著短于对照组(P<0.05)。治疗后,两组血清P、β-HCG、PAPP-A及VEGF浓度均显著升高(P<0.05),而CA125含量均显著下降(P<0.05);且治疗组以上各项血清学标志物的改善效果显著好于对照组(P<0.05)。治疗后,两组子宫螺旋动脉血流动力学参数值均显著降低(P<0.05),且治疗组比对照组下降更为明显(P<0.05)。结论固肾安胎丸联合烯丙雌醇治疗先兆流产有助于迅速缓解患者临床症状,维持正常妊娠,整体疗效确切,且安全可靠。

Clinical study on Gushen Antai Pills combined with allylestrenol in treatment of threatened abortion

Objective To investigate the clinical effect of Gushen Antai Pills combined with allylestrenol in treatment of threatened abortion.Methods Patients(120 cases)with threatened abortion in Tianjin Dongli District,Dongli Hospital from June 2016 to December 2018 were randomly divided into control(60 cases)and treatment(60 cases)groups.Patients in the control group were po administered with Allylestrenol Tablets,1 tablet/time,three times daily.Patients in the treatment group were po administered with Gushen Antai Pills on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy was evaluated,and the relief time of main symptom,the serum level of P,β-HCG,CA125,PAPP-A and VEGF,hemodynamic parameters of uterine spiral artery in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 75.00%,which was significantly lower than 90.00%in the treatment group,and there were differences between two groups(P<0.05).After treatment,the relief time of vaginal bleeding,low back pain and lower abdomen falling pain in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the serum level of P,β-HCG,CA125,PAPP-A and VEGF in two groups was significantly increased(P<0.05),but the CA125 level was significantly decreased(P<0.05),and these serological markers in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the hemodynamic parameters of uterine spiral artery in two groups were significantly decreased(P<0.05),and which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Gushen Antai Pills combined with allylestrenol in treatment of threatened abortion can relieve the clinical symptoms,maintain normal pregnancy,has overall effect,with safety and reliability.