蛇床子的镇静催眠作用、宿醉反应和耐受性

目的研究蛇床子镇静催眠作用的有效性、宿醉反应和耐受性。方法观察蛇床子生药、醇提物对小鼠自主活动和对戊巴比妥钠催眠剂量潜伏期和睡眠时间的影响;观察蛇床子醇提物对小鼠醒后自主活动的影响,及其重复给药对自主活动和催眠实验的影响。结果蛇床子生药、65%、95%醇提物组小鼠自主活动次数显著低于空白对照组,且睡眠时间均显著长于空白对照组;地西泮、65%醇提物组小鼠睡前站立次数显著少于空白对照组;65%、95%醇提物组小鼠醒后活动次数均显著高于空白对照组;蛇床子生药、65%、95%醇提物组小鼠于给药第1、3、5、15天站立次数均少于空白对照组。对自主活动抑制作用是逐渐加强的,而地西泮对自主活动均数的影响在给药后的前5d逐渐减少,第15天次数增加。蛇床子各给药组睡眠时间均数随用药时间的延长而增加,而地西泮则反之。结论蛇床子镇静催眠作用显著,且宿醉反应和耐受性等较地西泮小。

Research on sedation, hypnosis, hangover response, and tolerance of Fructus Cnidii

Objective To study the efficacy, tolerance and hangover response of sedation and hypnosis of ethanol extract of Fructus Cnidii on mice. Methods Crude drug and ethanol of Fructus Cnidii were studied the effects on autonomic activities, and dose, latent period and duration of hypnosis sleep induced by sodium pentobarbital injection. The ethanol extracts were also studies the autonomic activities after sleep. The effects of repeated-dose on autonomic avtivities and hypnosis were also studied. Results Compared with the blank control group, the times of autonomic activities in groups of crude drug, 65% ethanol extract and 95% ethanol extract were significantly lower, and the sleep time in the groups of crude drug and ethanol extract was much longer. The frequencies of pre-sleep standing in diazepam group and 65% ethanol extract were significantly lower. The times of activities after sleep in the two ethanol extract groups were obviously more, and the times of standing on 1, 3, 5, 15 day after administration of crude drug, ethanol extracts were obviously less. The sleep time in experimental groups increased with the time after Fructus Cnidii administration, while decreased with diazepam administration. Fructus Cnidii ethanol extracts did not showed drug tolerance, while diazepam did. Conclusion Fructus Cnidii has a significant sedative and hypontic effects on mice, and the hangover response and tolerance are less than diazepam.