| 青蒿素及其衍生物用于治疗新型冠状病毒肺炎的探讨 |
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| 引用本文： | 刘桂梅,蔡楠,谢静,辛辰,李瑞明,周怀瑜,李荀,王成,何毅.青蒿素及其衍生物用于治疗新型冠状病毒肺炎的探讨[J].现代药物与临床,2020,43(4):606-612. |
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| 作者姓名： | 刘桂梅 蔡楠 谢静 辛辰 李瑞明 周怀瑜 李荀 王成 何毅 |
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| 作者单位： | 山东省胸科医院, 山东 济南 250013;天士力控股集团有限公司研究院 现代中药开发中心, 天津 300410;天士力医药集团股份有限公司 创新中药关键技术国家重点实验室, 天津 300410;山东大学 基础医学院, 山东 济南 250012;山东省医学科学院药物研究所, 山东第一医科大学, 山东 济南 250012 |
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| 基金项目： | 国家科技重大专项"中医药优势领域的创新中药关键技术开发研究"（2017ZX09301005）；山东省重点研发计划"新型冠状病毒潜在药物临床评价研究"（2020SFXGFY07） |
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| 摘 要： | 自2019年12月武汉首次出现新型冠状病毒肺炎（COVID-19），越来越多人被确诊，已经扩散到了中国各地和境外多个国家。由于尚没有特效药，很多已被批准的"老药"被用于COVID-19的临床治疗中。青蒿素是世界卫生组织推荐的一线抗疟药物，研究发现其还具有抗炎、免疫调节、抗肺纤维化、抗菌、抗病毒、心血管作用等多种药理作用。综述了青蒿素及其衍生物抗COVID-19相关的药理作用及其作用机制，以挖掘其潜在的药用价值，重点探讨了其用于治疗COVID-19的可行性，为发掘有效的治疗药物提供参考。
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| 关 键 词： | 青蒿素 新型冠状病毒肺炎 抗炎 免疫调节 抗肺纤维化 |
| 收稿时间： | 2020/3/8 0:00:00 |
Discussion on artemisinin and its derivatives for treatment of COVID-19 |
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| LIU Guimei,CAI Nan,XIE Jing,XIN Chen,LI Ruiming,ZHOU Huaiyu,LI Xun,WANG Cheng,HE Yi.Discussion on artemisinin and its derivatives for treatment of COVID-19[J].Drugs & Clinic,2020,43(4):606-612. |
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| Authors: | LIU Guimei CAI Nan XIE Jing XIN Chen LI Ruiming ZHOU Huaiyu LI Xun WANG Cheng HE Yi |
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| Institution: | Shandong Provincial Chest Hospital, Ji''nan 250013, China;TCM Research Center, Tasly Holding Group Co., Ltd., Tianjin 300410, China;State Key Laboratory of Critical Technology in Innovative Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd., Tianjin, 300410, China;Shandong University School of Basic Medical Sciences, Ji''nan 250012, China;Institute of Materia Medica, Shandong First Medical University & ShandongAcademy of Medical Sciences, Ji''nan 250012, China |
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| Abstract: | Since the initial cases of the Coronavirus Disease in 2019 (COVID-19) occurred in Wuhan in December 2019, more and more cases have been found and confirmed, not only in central China but also in other countries. Given there are still no effective drugs many approved "old drugs" are in clinical test for treating COVID-19 at present. Artemisinin, a first-line antimalarial drug recommended by WHO, has been validated to possess a variety of pharmacological effects, including, without limitation, antiinflammatory, immune regulation, anti-pulmonary fibrosis, antibacterial, antiviral and cardiovascular effects, and the like. In this paper, various pharmacological effects of Artemisinin and its derivatives have been summarized, with the emphasis on the mechanism of action, so as to explore its potential medicinal value, especially for treating COVID-19. |
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| Keywords: | artemisinin COVID-19 anti-inflammatory immune regulation anti-pulmonary fibrosis |
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