| 树脂分离纯化枳实中辛弗林的工艺研究 |
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| 引用本文： | 廖茂梁,尚海花,胡 静,王 阳,张铁军.树脂分离纯化枳实中辛弗林的工艺研究[J].现代药物与临床,2011,26(2):129-133. |
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| 作者姓名： | 廖茂梁 尚海花 胡 静 王 阳 张铁军 |
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| 作者单位： | 廖茂梁 (天津中医药大学,天津,300193) ； 尚海花 (天津药物研究院,天津,300193) ； 胡静 (天津中医药大学,天津,300193) ； 王阳 (天津中医药大学,天津,300193) ； 张铁军 (天津中医药大学,天津,300193) ； |
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| 基金项目： | 天津市自然科学基金资助项目,天津市科技支撑计划资助项目 |
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| 摘 要： | 目的 研究大孔吸附树脂对枳实中辛弗林的吸附性能,考察精制工艺.方法 以辛弗林质量分数和收率为考察指标,比较了HPD.300、NKA.9、AB.8、D001-cc 等树脂对枳实中辛弗林的吸附和解吸特性,以及纯化能力.结果 D001-cc 树脂具有最佳的吸附洗脱参数,上样液生药质量浓度为0.5 g生药/mL,4倍体积蒸馏水...
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| 关 键 词： | 枳实 辛弗林 树脂 D001-cc大孔离子树脂 吸附性能 |
Separation and purification of synephrine in Aurantii Immaturus Fructus by resin |
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| LIAO Mao-liang,SHANG Hai-hu,HU-Jing,WANG Yang and ZHANG Tie-jun.Separation and purification of synephrine in Aurantii Immaturus Fructus by resin[J].Drugs & Clinic,2011,26(2):129-133. |
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| Authors: | LIAO Mao-liang SHANG Hai-hu HU-Jing WANG Yang and ZHANG Tie-jun |
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| Institution: | 1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Objective To optimize the technology for purification of synephrine in Aurantii Immaturus Fructus by resins. Methods HPD300, NKA-9, AB-8, and D001-cc resins were used to separate and purify synephrine. The yields and purities of the products were compared as indexes. Results D001-cc type macroporous ion resin had optimum adsorption and elution parameters. The appropriate adsorption conditions were: the concentration of crud drug was 0.5 mg/mL, flow rate was 1 BV/h, the effect of desorption was satisfactory when 1.5 mol/L ammonia (2 BV) and water (4 BV) were used as eluant. Conclusion The D001-cc type macroreticular resin shows a better comprehensive adsorption property and can be used to separate and purify synephrine in Aurantii Immaturus Fructus. |
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| Keywords: | Aurantii Immaturus Fructus synephrine resins D001-cc macroporous ion resin adsorptivity |
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