贝前列素钠联合前列地尔治疗老年慢性肾衰竭的临床研究

目的探讨贝前列素钠片联合前列地尔注射液治疗老年慢性肾衰竭的临床疗效。方法选取2016年6月—2017年1月三门峡市中心医院收治的老年慢性肾衰竭患者68例,所有患者按照随机数字表法分为对照组和治疗组,每组各34例。对照组静脉滴注前列地尔注射液,10μg加入到生理盐水100 mL中,输注时间1~1.5 h,1次/d,连续治疗4周。治疗组静脉滴注前列地尔注射液,用法用量同对照组,连续治疗2周;然后口服贝前列素钠片,40μg/次,3次/d,连续治疗2周。观察两组的临床疗效,比较两组的肾功能、血脂和血液流变学的情况。结果治疗后,对照组和治疗组的总有效率分别为67.65%、88.24%,两组比较差异有统计学意义(P0.05)。治疗后,两组血肌酐(Scr)、肾小球滤过率(GFR)、24 h尿蛋白定量显著降低,而血胱抑素(Cys-C)显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组总胆固醇(TC)、三酰甘油(TG)、全血低切黏度和全血高切黏度均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论贝前列素钠片联合前列地尔注射液治疗老年慢性肾衰竭具有较好的临床疗效,能改善肾功能,调节血脂和血液黏度,具有一定的临床推广应用价值。

Clinical study on beraprost sodium combined with alprostadil in treatment of senile chronic renal failure

Objective To investigate the effect of Beraprost Sodium Tablets combined with Alprostadil Injection in treatment of senile chronic renal failure. Methods Elderly patients (68 cases) with chronic renal failure in Sanmenxia Central Hospital from June 2016 to January 2017 were randomly divided into control and treatment groups, and each group had 34 cases. Patients in the control group were iv administered with Alprostadil Injection, 10 μg added into 100 mL normal saline, infusion time for 1 — 1.5 h, once daily, treated for 4 weeks. Patients in the treatment group were iv administered with Alprostadil Injection, usage and dosage same as the control group, treated for 2 weeks, then patients in the treatment group were po administered with Beraprost Sodium Tablets, 40μg/time, three times daily, treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and renal function, blood lipid, and hemorheology were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 67.65%and 88.24%, respectively, and there was difference between two groups (P < 0.05). After treatment, Scr, GFR, and 24 h urine protein quantity in two groups were significantly decreased, but the Cys-C in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, TC, TG, whole blood low shear viscosity, and whole blood high shear viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Beraprost Sodium Tablets combined with Alprostadil Injection has clinical curative effect in treatment of senile chronic renal failure, can improve renal function and regulate blood lipid, and blood viscosity, which has a certain clinical application value.