| 熊去氧胆酸软胶囊的制备工艺研究 |
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| 引用本文： | 邹华生,刘新红,仲婕,周婷婷.熊去氧胆酸软胶囊的制备工艺研究[J].中国现代应用药学,2009,26(4):297-299. |
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| 作者姓名： | 邹华生 刘新红 仲婕 周婷婷 |
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| 作者单位： | 浙江九旭药业有限公司,浙江 金华 321016 |
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| 摘 要： | 目的 研究熊去氧胆酸软胶囊的制备工艺。方法通过不同处方与工艺对比研究，确定本制剂处方及制备方法，并进行中试试验。结果以大豆油为基质，蜂蜡为助悬剂，80℃混匀，室温下压丸，处方组成及制备工艺合理，制剂稳定。结论工艺可行，适合工业化生产。
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| 关 键 词： | 熊去氧胆酸 软胶囊 制剂工艺 高效液相色谱法 |
| 收稿时间： | 1/1/1900 12:00:00 AM |
Study on the Prepared Technology of Ursodeoxycholic Acid Soft Capsules |
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| ZOU Huasheng,LIU Xinhong,ZHONG Jie,ZHOU Tingting.Study on the Prepared Technology of Ursodeoxycholic Acid Soft Capsules[J].The Chinese Journal of Modern Applied Pharmacy,2009,26(4):297-299. |
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| Authors: | ZOU Huasheng LIU Xinhong ZHONG Jie ZHOU Tingting |
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| Institution: | ( Zhejiang Jiuxu Pharmaceutical Co. , Ltd. , Jinhua 321016, China) |
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| Abstract: | OBJECTIVE To study the preparation technology of ursodeoxycholic acid soft capsules. METHODS With using different formulation and process, the ursodeoxycholie acid soft capsules were prepared, then the best were selected in the pilot preparation. RESULTS By mixing ursodeoxycholic acid and soybean oil and beeswax at 80℃ and preparing at room temperature. The formulations and process was reasonable. The finished product was stable. CONCLUSION This prepared technology is compatible with industrialisation. |
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| Keywords: | polysaccharide thermosensitive gel poloxamer phase-transition temperature phase-transition time |
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