葛根素对高血压患者血浆内皮素和一氧化氮的影响

目的：检测正常人与高血压病（ＥＨ）患者血浆内皮素、一气体氮的变化及葛根素对其的干预效应。方法：ＥＨ对照组口服苯磺酸氨氯地平５ｍｇ／ｄ，或合和盐酸苯那普利１０ｍｇ／ｄ，每日一次，１５ｄ为一疗程。ＥＨ伍用治疗组同时合用５％ＧＮＳ２５０ｍｌ＋葛根素注射液４００ｍｇ静滴，两组治疗前后检测血浆ＥＴ、ＮＯ水平变化。结果：ＥＨ各组血浆ＥＴ较正常人组均显著增高（Ｐ〈０．０１），血浆ＮＯ水平及ＮＯ／ＥＴ比值除轻度Ｅ

Effects of puerarin on plasma endothelin and nitric oxide in patients with essential hypertension

OBJECTIVE:To evaluate the alteration of plasma Endothelin(ET)and Nitric Oxide(NO)in patients with Essential Hypertension(EH),and the involvement of treatment with puerarin.METHODS:Two different treatments were set up as follows:P.0.5mg amlodipine or/and 10mg benazepril(AML or/and BEN),AML or/and BEN combinated with iv gtt 400mg puerarin in 250ml 5% GNS,qd,every 15 days was taken as a treatment course.The alteration of plasma ET and NO was measured before and after the treatments,and the differences between the two groups were compared.RESULTS:Compared with the health control group,the plasma ET of the EH in each group was significantly higher(P<0.05,P< 0.01 ),while the levels of plasma NO and the NO/ET ratio were markedly lower except those in mild EH group(P<0.01),The levels of plasma ET and NO as well as NO/ET ratio were positively or negatively correlated with diastolic blood pressure,respectively(r=0.955,r=-0.931,r=-0.973).There were markedly differences of plasma ET and NO between the two groups(P<0.05),as well as before and after treatment of AML or/and BEN combinated with puerarin,respectively(P<0.01,P<0.05).CONCLUSION:The increased Plasma ET or decreased Plasma NO were well correlated with EH.Puerarin could adjust the levels of plasma ET and NO companying down-adjusting blood pressure effect.