| 5-Fu/PLGA 微球的制备 |
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| 引用本文： | 沈正荣,朱家蕙,张伟军,马臻.5-Fu/PLGA 微球的制备[J].中国现代应用药学,1993(3):14-16. |
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| 作者姓名： | 沈正荣 朱家蕙 张伟军 马臻 |
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| 作者单位： | 浙江省医学科学院，浙江省医学科学院，浙江省医学科学院，浙江省医学科学院 杭州 310013，杭州 310013，杭州 310013，杭州310013 |
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| 摘 要： | 以可生物降解高分子材料乳酸—羟乙酸共聚物(PLGA)为载体,以5—氟脲嘧啶(5-Fu)为活性药物,用相分离—凝聚法制备了可供肿瘤动脉栓塞化疗用微球,并进行了初步的微球体外药物释放试验。
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| 关 键 词： | 乳酸—羟乙酸共聚物 5—氟脲嘧啶 相分离(?)凝聚法 动脉栓塞 |
Preparation of Poly(DL-lactide-co-glycolide)Microspheres Containing 5-Fluorouracile |
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| Shen Zhengrong Zhu Jiahuei Zhang Weijun Ma Zheng.Preparation of Poly(DL-lactide-co-glycolide)Microspheres Containing 5-Fluorouracile[J].The Chinese Journal of Modern Applied Pharmacy,1993(3):14-16. |
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| Authors: | Shen Zhengrong Zhu Jiahuei Zhang Weijun Ma Zheng |
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| Abstract: | An attempt is being made to develop poly(DL-lactide-co-glycolide)(PLGA)
microspheres containing 5-fluorouracile(5-Fu)as a new anticancer preparation for tumour
arterial chemoembolization therapy.
Thus,PLGA was synthesized by ring-opening polymerization of DL-lactide and glycolide,
and PLGA microspheres containing 5-Fu were prepared by a phase separation and deposition
process. |
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| Keywords: | Poly(DL-lactide-co-glycolide) 5-Fluorouracile Microspheres |
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