| EGFRIs相关性皮肤不良反应研究进展 |
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| 引用本文： | 王佩,汪斌,刘康,甘甲甲,陈俊,葛海涛.EGFRIs相关性皮肤不良反应研究进展[J].中国现代应用药学,2020,37(14):1788-1792. |
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| 作者姓名： | 王佩 汪斌 刘康 甘甲甲 陈俊 葛海涛 |
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| 作者单位： | 中国药科大学；南京苏中药物研究有限公司,南京苏中药物研究有限公司,中国药科大学,南京苏中药物研究有限公司,南京苏中药物研究有限公司,南京苏中药物研究有限公司 |
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| 摘 要： | 表皮生长因子受体抑制剂(EGFRIs)作为目前癌症领域应用最广泛的分子靶向治疗药物，其代表药物包括吉非替尼、厄洛替尼和埃克替尼等。在EGFRIs取得疗效的同时，其给患者带来的皮肤不良反应也不容忽视，严重时可影响癌症患者用药剂量，甚至中断治疗。文章主要对EGFRIs引起皮肤不良反应的发生机制进行综述，包括对角质形成细胞的增殖、凋亡、分化的影响,激活炎症反应及增加皮肤光敏性，为减轻药物不良反应，提高患者用药依从性，提高肿瘤疗效提供新的治疗思路。
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| 关 键 词： | 表皮生长因子受体抑制剂 不良反应 发生机制 角质形成细胞 |
| 收稿时间： | 2019/7/20 0:00:00 |
| 修稿时间： | 2019/12/6 0:00:00 |
Research Progress on EGFRIs Related Adverse Skin Reactions |
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| WANG Pei,WANG Bin,LIU Kang,GAN Jiaji,CHEN Jun,GE Haitao.Research Progress on EGFRIs Related Adverse Skin Reactions[J].The Chinese Journal of Modern Applied Pharmacy,2020,37(14):1788-1792. |
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| Authors: | WANG Pei WANG Bin LIU Kang GAN Jiaji CHEN Jun GE Haitao |
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| Institution: | China Pharmaceutical University,School of Traditional Chinese Medicine,Nanjing, Jiangsu Nanjing Suzhong Pharmaceutical Research Company,Nanjing,Nanjing Suzhong Pharmaceutical Research Company,China Pharmaceutical University,School of Traditional Chinese Medicine,Nanjing, Jiangsu Nanjing Suzhong Pharmaceutical Research Company,Nanjing,Nanjing Suzhong Pharmaceutical Research Company,Nanjing Suzhong Pharmaceutical Research Company,Nanjing Suzhong Pharmaceutical Research Company |
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| Abstract: | The human epidermal growth factor receptor inhibitors(EGFRIs) are the most widely used molecular targeted therapy drugs in cancer field. The representative drugs includes gifetinib, erlotinib, and ectatinib. While EGFRIs achieve efficacy, the adverse skin reactions brought by them can not be ignored. In severe cases, they can affect the dose of cancer patients and even interrupt treatment. This paper reviews the manifestation and mechanism of adverse skin reactions caused by EGFRIs,including alterations of keratinocyte proliferation,differentiation and apoptosis,enhanced inflammatory response and photosensitivity to ultraviolet radiation. It is expected that these mechanism studies will provide new treatment ideas to reduce the adverse drug reaction, improve the patient drug compliance, improve tumor efficacy . |
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| Keywords: | epidermal growth factor receptor inhibitors adverse reactions occurrence mechanism keratin forming cells |
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