荷移分光光度法测定乳酸环丙沙星乳膏的含量

目的：建立乳酸环丙沙星乳膏的含量测定方法。方法：利用乳酸环丙沙星与2.4-二硝基酸产生反应，可形成电荷转移络合物，以分光光度法测定。结果：荷移反应后，乳酸环丙沙星最大吸收波长为398nm，在此波长处基质无干扰，吸收度与浓度间呈良好的线性关系，平均回收率为98.6%,RSD=0.8%(n=4)。结论：用荷移分光光度法可排除基质干扰，准确测定乳酸环丙沙星乳膏的含量。

Determination of ciprofloxacin lactate cream by charge transfer spectrophotometry

OBJECTIVE:To establish a metod for the determination of ciprofloxacin lactate cream. METHOD:To utilize the reaction of ciprofloxacin lactate and 2.4 dinitroresorcinol to form the charge transfer complex compound that was measured by UV spectrophotometry.RESULTS:The maximum absorption wavelength of the complex compound was 398nm.There is no base absorption.The absorptions and the concentrations have good liner relationship.The average rate of recovery was 98.6%,RSD=0.8%( n =4).CONCLUSION:The method of change transfer spectrophotometry can remove interference of base and exactly measure the content of ciprofloxacin lactate cream.