| 复方丹参胶囊对实验性心肌梗塞的保护作用 |
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| 引用本文： | 肖东,赵雪英,毛棣华#,顾振纶,钱曾年;周文轩,郭次仪.复方丹参胶囊对实验性心肌梗塞的保护作用[J].中国现代应用药学,1994(1):20-23. |
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| 作者姓名： | 肖东 赵雪英 毛棣华# 顾振纶 钱曾年;周文轩 郭次仪 |
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| 作者单位： | 苏州中药研究所(肖东，赵雪英，毛棣华，顾振纶，钱曾年)，香港百草堂有限公司(周文轩，郭次仪) |
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| 摘 要： | 用麻醉大鼠冠状动脉前降支结扎造成急性心肌梗塞模型，观察了复方丹参胶囊对心肌梗塞的作用。复方丹参胶囊６０、１２０ｍｇ／ｋｇ于冠脉结扎前ｉｐ，显著降低结扎后５ｈ的心肌梗塞范围，并使血清磷酸肌酸激酶（ＣＰＫ）活性明显降低，保护心肌ＳＯＤ活性，减轻心肌超微结构的病理改变。提示复方丹参胶囊对实验性心肌梗塞具有明显的保护作用。这种作用可能与其抗心肌脂质过氧化有关．
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| 关 键 词： | 复方丹参胶囊，心肌梗塞，SOD，超微结构 |
Protective Effects of Danshen Co on ExperimentalMyocardial infarction |
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| Xiao Dong; Zhao Xueyin; Gu Zhenlun; Qian Zengnian;Mao Dihua Zhou Wenxuan; Guo Chiyi.Protective Effects of Danshen Co on ExperimentalMyocardial infarction[J].The Chinese Journal of Modern Applied Pharmacy,1994(1):20-23. |
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| Authors: | Xiao Dong; Zhao Xueyin; Gu Zhenlun; Qian Zengnian;Mao Dihua Zhou Wenxuan; Guo Chiyi |
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| Abstract: | The effects of Danshen Co (CDS) on experimental myocardial infarction were studiedin anaesthetized rats. CDS 60, 120 mg.kg-l ip decreased CPK and myocardial infarct scope, greatly protected myocardial SOD actiyity, and alleviated the pathologic changes of the ultrastructure of infarct myocyte. The results indicated that CDS had protective effects against myocardial infarction probably by free radicals and subsequent lipid peroxidation. |
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| Keywords: | Capsule of Danshen Co Myocardial infarction Superoxide Dsmutase Ultrastructure |
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