Synthesis and antitumor activity evaluation of lamiridosin A derivatives |
| |
| Authors: | Yan-Xia Yang Jian-Wei Yan Fang-Fang Zhuang Zi-Yang Ji |
| |
| Institution: | Pharmacy College, Xinxiang Medical University, Xinxiang 453003, China |
| |
| Abstract: | A series of lamiridosin A derivatives were synthesized through simple procedures. Their antitumor activities were evaluated against EC9706, MGC803, and B16 cell lines in vitro. Several compounds showed potent antitumor activity, especially compound 10, with IC50 value of 2.36 μmol/L against MGC803 cell lines, is more potent than marketed positive drug 5-fluorouridine (5-FU). |
| |
| Keywords: | Lamiridosin A iridoids ether derivatives triazole antitumor |
|
|
