Three new monoterpenoid indole alkaloids from Vinca major |
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| Authors: | Zhi-Jun Zhang Ru-Nan Du Juan He Xing-De Wu Yan Li |
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| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, China |
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| Abstract: | Three new monoterpenoid indole alkaloids, 19-hydroxyl-10-methoxy-19, 20-dihydrovinorine (1), 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine (2), and 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine (3), along with five known analogues (4–8), were isolated from the whole plants of Vinca major. The new structures were elucidated by extensive NMR and MS analysis and comparison with known compounds. In addition, compounds 1–3 were evaluated for their cytotoxicities against five human cancer cell lines. |
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| Keywords: | Apocynaceae Vinca major monoterpenoid indole alkaloid cytotoxicity |
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