Perangustols A and B,a pair of new azaphilone epimers from a marine sediment-derived fungus Cladosporium perangustm FS62 |
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| Authors: | Zhen Fan Zhang-Hua Sun Hong-Xin Liu Yu-Chan Chen Hao-Hua Li |
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| Institution: | 1. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;2. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510006, China;3. College of Earth Sciences, University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A pair of new azaphilone epimers, perangustols A-B (1–2), and two new natural products (3–4), together with two known metabolites (5–6) were isolated from the culture of the marine sediment-derived fungus Cladosporium perangustum FS62. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The isolated compounds (1–6) were evaluated for their cytotoxic activities against the SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. Nonetheless, no significant activity was observed. |
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| Keywords: | Marine fungus Cladosporium perangustum azaphilone perangustols |
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