Cytotoxic triterpene saponins from Clematis mandshurica |
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| Authors: | Yu-Xin He Kang Zhang Zhong-Rong Liu |
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| Affiliation: | 1. Bioengineering College, Xihua University , Chengdu, Sichuan, 610039, China;2. Chengduzhihao Pharmaceutical Co., Ltd, The Life Science and Technology Park, Chengdu High Tech Zone , Sichuan, 610041, China |
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| Abstract: | Two new triterpene saponins, mandshunosides A and B (1 and 2), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1 and 2 showed inhibitory activities against two colorectal human cancer cells HCT 116 (IC50 2.1 μM for 1 and 2.5 μM for 2) and HT-29 (IC50 3.7 μM for 1 and 3.3 μM for 2). |
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| Keywords: | Clematis mandshurica triterpene saponins mandshunoside A mandshunoside B cytotoxicity |
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