| 激活沉默基因以产生新抗生素的研究进展 |
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| 引用本文： | 邢芸,刘景晶,顾觉奋.激活沉默基因以产生新抗生素的研究进展[J].国外医药(抗生素分册),2010,31(2):49-53. |
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| 作者姓名： | 邢芸 刘景晶 顾觉奋 |
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| 作者单位： | 中国药科大学生命科学与技术学院,南京,210009 |
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| 基金项目： | （致谢：感谢南京卡德投资管理有限公司的支持与帮助.） |
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| 摘 要： | 基因工程技术的不断成熟使得人们寻找新抗生素和新生理活性物质的途径更加多样化，更具针对性。本文将具体介绍一种利用重金属选择压力激活金属耐受放线菌的沉默基因以获得新抗生素的方法，以及人们分析基因组测序发现很多隐藏的生物合成基因簇得到大量新的生物活性物质的方法，为今后科研工作做参考。
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| 关 键 词： | 沉默基因 激活 抗生素 重金属 基因组 |
Progression on New Antibiotic Development by Arousing Silent Gene |
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| Xing Yun,Liu Jing-jing,Gu Jue-fen.Progression on New Antibiotic Development by Arousing Silent Gene[J].world notes on antibiotics,2010,31(2):49-53. |
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| Authors: | Xing Yun Liu Jing-jing Gu Jue-fen |
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| Institution: | (Institute of Life Science and Technology, China Pharmaceutical Univercity, Nanjing 210009, Chian) |
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| Abstract: | As the rapid development of gene engineering techniques, the various screening methods for the development of new antibiotics and bio-active substances has been established. This article introduces a new method that, under the heavy metal stress, activate the silent genes of heavy metal resistant Actinomyces and obtain new antibiotics. Moreover, the various methods for discovering bio-active new substances through cryptic biosynthetic gene clusters were established and summarized in this article. |
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| Keywords: | silent gene activation antibiotics heavy metal genomes |
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