阿奇霉素序贯治疗小儿支原体肺炎与药物性肝炎的相关性研究

目的探讨不同剂量阿奇霉素序贯疗法治疗不同年龄段小儿支原体肺炎,引发药物性肝炎的发生率,为临床合理用药,防止不良反应提供科学依据。方法选取符合标准的240例支原体肺炎患儿,按年龄大小分成3个年龄段,每个年龄段内随机分成阿奇霉素10mg/（kg·d）治疗组及8mg/（kg·d）治疗组,各40例。结果阿奇霉素序贯治疗不同年龄段患儿与引起药物性肝炎发生率存在相关性,年龄愈小,发生率愈高。结论不同年龄段支原体肺炎感染小儿应合理使用阿奇霉素,以免引起药物性肝炎。

Study on the Interrelation between MP treated by sequential therapy with Azithromycin and drug hepatitis

Objective To investigate the rate of drug hepatitisof Adriamycinafter sequential therapy at different age groups. And to supply the reasonable guide for using medication on clinical. Methods 240 caces with MP were divided into three groups by age. Each group was randomly divided into two groups： group Azithromycin 10 mg/（ kg·d） （ 40 cases） and group Azithromycin 8 mg/（ kg·d） （ 40 cases） . Results There are interrelations between MP treated by sequential therapy with Azithromycin and drug hepatitis,and the age is younger the rate of drug hepatitis is higher. Conclusion The young child should use the Azithromycin base on different ages,so as not to cause drug hepatitis.