丁螺环酮与帕罗西汀联合治疗焦虑症患者的临床效果探讨

目的探讨焦虑症患者应用丁螺环酮联合帕罗西汀治疗的临床效果。方法 80例焦虑症患者,采用抽签法分为对照组和观察组,每组40例。对照组患者采用帕罗西汀治疗,观察组患者采用丁螺环酮联合帕罗西汀治疗。比较两组患者的治疗效果、治疗前后焦虑自评量表(SAS)评分以及治疗期间不良反应发生情况。结果观察组患者的治疗总有效率为95.00%,显著高于对照组的75.00%,差异具有统计学意义(P<0.05)。治疗前,两组患者SAS评分比较差异无统计学意义(P>0.05);治疗后,两组患者的SAS评分均显著低于本组治疗前,且观察组低于对照组,差异均具有统计学意义(P<0.05)。观察组患者治疗期间不良反应发生率为5.00%,显著低于对照组的20.00%,差异无统计学意义(P<0.05)。结论焦虑症患者采取丁螺环酮联合帕罗西汀治疗,能够提高治疗效果,改善焦虑状态,同时减少用药不良反应。

Discussion on clinical effect of buspirone combined with paroxetine in the treatment of anxiety patients

Objective To discuss the clinical effect of buspirone combined with paroxetine in the treatment of anxiety patients. Methods A total of 80 anxiety patients were divided into control group and observation group by lottery method, with 40 cases in each group. The control group was treated by paroxetine, and the observation group was treated by buspirone combined with paroxetine. The therapeutic effect, self-rating anxiety scale(SAS) score before and after treatment, and occurrence of adverse reactions during treatment was compared between the two groups. Results The total effective rate of treatment was 95.00% in the observation group, which was significantly higher than 75.00% in the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in SAS score between the two groups(P>0.05). After treatment, the SAS score in the two groups was significantly lower than those before treatment, and the observation group was lower than the control group. Their difference was statistically significant(P<0.05). The incidence of adverse reactions during treatment was 5.00% in the observation group, which was significantly lower than 20.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion Buspirone combined with paroxetine can improve the therapeutic effect of anxiety patients and reduce the occurrence of adverse drug reations.