苯巴比妥联合地西泮治疗急诊小儿惊厥的效果观察

目的观察苯巴比妥联合地西泮治疗急诊小儿惊厥的临床效果。方法94例惊厥患儿,采用随机数字表法分为对照组和研究组,各47例。对照组给予地西泮治疗,研究组给予苯巴比妥联合地西泮治疗。比较两组患儿临床疗效、惊厥症状控制时间、实验室相关指标及复发率。结果研究组总有效率95.74%高于对照组的72.34%,差异有统计学意义(P<0.05)。研究组惊厥症状控制时间(11.11±2.03)min短于对照组的(15.27±3.13)min,差异有统计学意义(P<0.05)。用药7 d后,两组血清神经元特异性烯醇化酶(NSE)、血清脑源性神经营养因子(BNDF)、血清S-100β蛋白(S-100)水平均低于用药前,且研究组NSE(25.05±2.13)ng/ml、BNDF(6.71±1.05)μg/L、S-100(0.15±0.03)μg/L低于对照组的(31.03±2.29)ng/ml、(12.29±1.15)μg/L、(0.29±0.05)μg/L,差异有统计学意义(P<0.05)。随访1个月,研究组复发率为2.13%(1/47),低于对照组的12.77%(6/47),差异有统计学意义(P<0.05)。结论在急诊小儿惊厥治疗中实施苯巴比妥联合地西泮治疗方案,能够更好的改善患儿血清学指标,缩短症状控制时间,更好的改善惊厥症状,提升临床治疗效果,并降低复发率,具有较高的临床推广价值。

Observation on the effect of phenobarbital combined with diazepam in the treatment of infantile convulsions in emergency department

Objective To observe the clinical effect of phenobarbital combined with diazepam in the treatment of infantile convulsions in emergency department.Methods A total of 94 cases of infantile convulsions were divided into control group and research group by random numerical table,with 47 cases in each group.The control group was treated with diazepam,and the research group was treated with phenobarbital in combination with diazepam.Comparison were made on clinical efficacy,control time of convulsion symptoms,laboratoryrelated indicators and recurrence rate between the two groups.Results The total effective rate 95.74%of the research group was higher than 72.34%of the control group,and the difference was statistically significant(P<0.05).The control time of convulsion symptoms(11.11±2.03)min in the research group was shorter than(15.27±3.13)min in the control group,and the difference was statistically significant(P<0.05).After 7 d of treatment,the levels of serum neuron-specific enolase(NSE),serum brain-derived neurotrophic factor(BNDF),and serum S-100 protein in the two groups were lower than before treatment in this group;the NSE(25.05±2.13)ng/ml,BNDF(6.71±1.05)μg/L,S-100(0.15±0.03)μg/L in the research group were lower than(31.03±2.29)ng/ml,(12.29±1.15)μg/L,(0.29±0.05)μg/L in the control group;all the differences were statistically significant(P<0.05).After 1 month of follow-up,the recurrence rate of the research group was 2.13%(1/47),which was lower than 12.77%(6/47)of the control group,and the difference was statistically significant(P<0.05).Conclusion The implementation of phenobarbital combined with diazepam in the treatment of emergency pediatric convulsions can better improve the serological indexes of children,shorten the time of symptom control,better improve the symptoms of convulsions,enhance the clinical therapeutic effect,and reduce the recurrence rate,which has high clinical promotion value.