小切口胆囊切除术治疗胆结石伴胆囊炎的效果观察

目的探讨小切口胆囊切除术治疗胆结石伴胆囊炎的效果。方法68例胆结石伴胆囊炎患者,采用随机数字表法分为对照组和实验组,每组34例。对照组行开腹胆囊切除术治疗,实验组行小切口胆囊切除术治疗。比较两组治疗前后疼痛介质因子指标(白细胞介素-6、心肌细胞P物质、前列腺素E2)、手术时间以及住院时间、并发症发生情况。结果术前,两组白细胞介素-6、心肌细胞P物质、前列腺素E2水平比较,差异无统计学意义(P>0.05);术后24 h,两组白细胞介素-6、心肌细胞P物质、前列腺素E2水平均显著高于术前,实验组白细胞介素-6(6.56±0.81)μg/ml、心肌细胞P物质(5.45±0.71)pg/ml、前列腺素E2(131.10±16.10)μg/ml均显著低于对照组的(8.82±0.91)μg/ml、(7.25±0.20)pg/ml、(181.34±24.45)μg/ml,差异具有统计学意义(P<0.05)。实验组手术时间(61.13±1.24)min以及住院时间(9.56±0.12)d均短于对照组的(75.31±2.75)min、(12.21±2.21)d,差异具有统计学意义(P<0.05)。实验组并发症发生率5.88%(2/34)低于对照组的29.41%(10/34),差异具有统计学意义(P<0.05)。结论胆结石伴胆囊炎患者实施小切口胆囊切除术治疗的效果确切,可改善患者病情,减少并发症,缩短治疗和康复时间,减轻对患者产生的不良应激。

Observation the effect of small incision cholecystectomy in the treatment of gallstones with cholecystitis

Objective To discuss the effect of small incision cholecystectomy in the treatment of gallstones with cholecystitis.Methods A total of 68 patients with gallstones and cholecystitis were divided into control group and experimental group by random numerical table,with 34 cases in each group.The control group was treated with open cholecystectomy,and the experimental group was treated with small incision cholecystectomy.The pain mediator factors(interleukin-6,cardiomyocyte substance P,prostaglandin E2)before and after treatment,operation time,hospitalization time,and complications were compared between the two groups.Results Before operation,there was no statistically significant difference in the levels of interleukin-6,cardiomyocyte substance P,and prostaglandin E2 between the two groups(P>0.05).At 24 h postoperatively,the levels of interleukin-6,cardiomyocyte substance P,and prostaglandin E2 in the two groups were significantly higher than those of this group before operation;the interleukin-6(6.56±0.81)μg/ml,cardiomyocyte substance P(5.45±0.71)pg/ml,and prostaglandin E2(131.10±16.10)μg/ml of the experimental group were significantly lower than(8.82±0.91)μg/ml,(7.25±0.20)pg/ml,and(181.34±24.45)μg/ml of the control group;all the differences were statistically significant(P<0.05).The operation time(61.13±1.24)min and hospitalization time(9.56±0.12)d in the experimental group were shorter than(75.31±2.75)min and(12.21±2.21)d in the control group,and the difference was statistically significant(P<0.05).The complication rate 5.88%(2/34)of the experimental group was lower than 29.41%(10/34)of the control group,and the difference was statistically significant(P<0.05).Conclusion Small incision cholecystectomy is effective in the treatment of patients with gallstones and cholecystitis,which can improve the patient's condition,reduce complications,shorten the time of treatment and rehabilitation,and reduce the adverse stress on patients.