| 葛根素葡萄糖注射液对犬实验性心肌缺血的影响 |
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| 引用本文： | 张秀芹,侯金玲,朱燕,李杰,徐淑兰,王芃,解砚英,XIE Yan-ying.葛根素葡萄糖注射液对犬实验性心肌缺血的影响[J].中国新药杂志,2001,10(4):272-274. |
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| 作者姓名： | 张秀芹 侯金玲 朱燕 李杰 徐淑兰 王芃 解砚英 XIE Yan-ying |
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| 作者单位： | 1. 山东省医科院药物所药理室,
2. Department of Pharmacology,Shandong Academy of Medical Sciences, |
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| 摘 要： | 目的观察葛根素葡萄糖注射液对犬急性心肌缺血的影响。方法结扎犬冠状动脉左前降支造成急性心肌缺血模型，葛根素葡萄糖注射液83mg*kg-1连续4h静脉滴注，观察心外膜电图、酶及心肌病理染色（N-BT）的变化。结果葛根素葡萄糖注射液可明显改善心电图指标，限制心肌梗死范围，降低血清肌酸激酶(CK)，肌酸激酶同工酶(CK-MB)，AST，乳酸脱氢酶(LDH)水平。结论葛根素葡萄糖注射液对犬实验性心肌缺血有较好的治疗作用。
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| 关 键 词： | 葛根素葡萄糖注射液 急性心肌缺血 冠状动脉结扎 |
| 文章编号： | 1003-3734（2001）04-0272-03 |
| 修稿时间： | 2000年5月16日 |
The effect of puerarin
glucose injection on experimental acute myocardial ischemia in dogs |
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| ZHANG Xiu-qin,HOU Jin-ling,Jin-ling,ZHU Yan,LI Jie,XU Shu-lan,WANG Peng,XIE Yan-ying.The effect of puerarin
glucose injection on experimental acute myocardial ischemia in dogs[J].Chinese Journal of New Drugs,2001,10(4):272-274. |
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| Authors: | ZHANG Xiu-qin HOU Jin-ling Jin-ling ZHU Yan LI Jie XU Shu-lan WANG Peng XIE Yan-ying |
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| Abstract: | Objective:To study the effects of puerarin glucose injection (PGI) on acute myocardial ischemia (AMI) induced by left descending anterior coronary artery ligation in dogs.Methods:The effects of PGI 83mg*kg-1 given by continuous 4h infusion on AMI induced by method mentioned above,were observed by epicardial electrogram,myocardial enzymes and histomorphometrical studies.Results:PGI could obviously improving the epicardial electrogram,decreasing the myocardial enzyme level, confining the seize of myocardial infarct,and decreasing the serum CK,CK-MB,AST,and LDH level.Conclusion:PGI is effective in treatment of experimental AMI in dogs. |
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